Evidence map›Paper›PMID 33073159›Full record

ArticleJournal of the Endocrine Society2020

Long-Term Results of Treating With Ethanol Ablation 15 Adult Patients With cT1aN0 Papillary Thyroid Microcarcinoma.

Ian D Hay, Robert A Lee, Suneetha Kaggal, John C Morris, Marius N Stan, M Regina Castro, Vahab Fatourechi, Geoffrey B Thompson, J William Charboneau, Carl C Reading

Open access · goldAbstract read
In one paragraph

Article in Journal of the Endocrine Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Guideline
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Nonsurgical Management of Thyroid Nodules: The Role of Ablative Therapies.The Journal of clinical endocrinology and metabolism · 2022
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ian D HayDepartments of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.ORCID 0000-0003-2317-3820
Robert A LeeDepartments of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.ORCID 0000-0001-8606-9268
Suneetha KaggalDepartments of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
John C MorrisDepartments of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Marius N StanDepartments of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.ORCID 0000-0002-1408-8125
M Regina CastroDepartments of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.ORCID 0000-0003-2784-8776
Vahab FatourechiDepartments of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Geoffrey B ThompsonDepartments of Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
J William CharboneauDepartments of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Carl C ReadingDepartments of Radiology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
Mayo Clinic · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurrently acceptable management options for patients with adult papillary thyroid microcarcinoma (APTM) range from immediate surgery, either unilateral lobectomy or bilateral lobar resection, to active surveillance (AS). An alternative minimally invasive approach, originally employed for eliminating neck nodal metastases, may be ultrasound-guided percutaneous ethanol ablation (EA). Here we present our experience of definitively treating with EA 15 patients with APTM. PATIENTS AND

methodsDuring 2010 through 2017, the 15 cT1aN0M0 patients selected for EA were aged 36 to 86 years (median, 45 years). Tumor volumes (n = 17), assessed by sonography, ranged from 25 to 375 mm

resultsThe ablated patients have now been followed for 10 to 100 months (median, 64 months). There were no complications and no ablated patient developed postprocedure recurrent laryngeal nerve dysfunction. All 17 ablated tumors shrank (median 93%) and Doppler flow eliminated. Median tumor volume reduction in 9 identifiable avascular foci was 82% (range, 26%-93%). After EA, 8 tumors (47%) disappeared on sonography after a median of 10 months. During follow-up no new PTM foci and no nodal metastases have been identified.

conclusionsDefinitive treatment of APTM by EA is effective, safe, and inexpensive. Our results suggest that, for APTM patients who do not wish neck surgery and are uncomfortable with AS, EA represents a well-tolerated and minimally invasive outpatient management option.

Indexed as

ethanol ablationmicrocarcinomamorbidityoutcomePTCsurgery

Identifiers

PMID33073159
PMCPMC7543935
OpenAlexW3092058121

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.