Evidence map›Paper›PMID 33073080›Full record

ArticleACS omega2020

Novel Approach for Characterizing Propofol Binding Affinities to Serum Albumins from Different Species.

Sergey Shityakov, Anneli Fischer, Kuan-Pin Su, Aqeel A Hussein, Thomas Dandekar, Jens Broscheit

Abstract read
In one paragraph

Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sergey ShityakovDepartment of Psychiatry and Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung 40402, Taiwan.
Anneli FischerDepartment of Anesthesia and Critical Care, Würzburg University Hospital, Würzburg 97080, Germany.
Kuan-Pin SuDepartment of Psychiatry and Mind-Body Interface Laboratory (MBI-Lab), China Medical University Hospital, Taichung 40402, Taiwan.
Aqeel A HusseinFaculty of Dentistry, University of Al-Ameed, 56001 Karbala, Iraq.
Thomas DandekarDepartment of Bioinformatics, Würzburg University, Würzburg 97074, Germany.
Jens BroscheitDepartment of Anesthesia and Critical Care, Würzburg University Hospital, Würzburg 97080, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interaction between the main carrier (serum albumin, SA) of endogenous and exogenous compounds in the bloodstream of different species (human, bovine, canine, rat, rabbit, and sheep) and a general anesthetic agent (propofol, PR) was investigated using an experimental technique (high-performance liquid chromatography) and computational methods (molecular docking, molecular dynamics, sequence, and phylogenetic analyses). The obtained results revealed the differences in the PR binding affinity to various homologous forms of this protein with reliable statistics (

Identifiers

PMID33073080
PMCPMC7557242

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.