Evidence map›Paper›PMID 33072965›Full record

ArticleInternational journal of neonatal screening2019

Newborn Screening for Sickle Cell Disease in the Caribbean: An Update of the Present Situation and of the Disease Prevalence.

Jennifer Knight-Madden, Ketty Lee, Gisèle Elana, Narcisse Elenga, Beatriz Marcheco-Teruel, Ngozi Keshi, Maryse Etienne-Julan, Lesley King, Monika Asnani, Marc Romana and 1 more

Abstract read
In one paragraph

Article in International journal of neonatal screening, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Review
  9. Advances and Gaps in Global Newborn Screening for Sickle Cell Disease.International journal of neonatal screening · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jennifer Knight-MaddenCaribbean Institute for Health Research-Sickle Cell Unit, The University of the West Indies, Mona, Kingston 7, Jamaica.ORCID https://orcid.org/0000-0002-0939-1648
Ketty LeeLaboratory of Molecular Genetics, Academic Hospital of Guadeloupe, 97159 Pointe-à-Pitre, Guadeloupe.
Gisèle ElanaReferral Center for Sickle Cell Disease, Department of Pediatrics, Academic Hospital of Martinique, 97261 Fort de France, Martinique, France.
Narcisse ElengaReferral Center for Sickle Cell Disease, Department of Pediatric Medicine and Surgery, Andrée Rosemon General Hospital, 97306 Cayenne, French Guiana, France.ORCID https://orcid.org/0000-0003-0624-4180
Beatriz Marcheco-TeruelNational Center of Medical Genetics, 11300 La Habana, Cuba.ORCID https://orcid.org/0000-0001-6009-0405
Ngozi KeshiPaediatric Department, Scarborough General Hospital, 00000 Scarborough, Tobago.
Maryse Etienne-JulanReferral Center for Sickle Cell Disease, Sickle Cell Unit, Academic Hospital of Guadeloupe, 97159 Pointe-à-Pitre, Guadeloupe, France.
Lesley KingCaribbean Institute for Health Research-Sickle Cell Unit, The University of the West Indies, Mona, Kingston 7, Jamaica.ORCID https://orcid.org/0000-0002-3995-9839
Monika AsnaniCaribbean Institute for Health Research-Sickle Cell Unit, The University of the West Indies, Mona, Kingston 7, Jamaica.ORCID https://orcid.org/0000-0002-7184-138X
Marc RomanaUMR Inserm 1134 Biologie Intégrée du Globule Rouge, Inserm/Université Paris Diderot-Université Sorbonne Paris Cité/INTS/Université des Antilles, Hôpital Ricou, Academic Hospital of Guadeloupe, 97159 Pointe-à-Pitre, Guadeloupe.ORCID https://orcid.org/0000-0002-8715-9836
Marie-Dominique Hardy-DessourcesUMR Inserm 1134 Biologie Intégrée du Globule Rouge, Inserm/Université Paris Diderot-Université Sorbonne Paris Cité/INTS/Université des Antilles, Hôpital Ricou, Academic Hospital of Guadeloupe, 97159 Pointe-à-Pitre, Guadeloupe.ORCID https://orcid.org/0000-0003-0861-3648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The region surrounding the Caribbean Sea is predominantly composed of island nations for its Eastern part and the American continental coast on its Western part. A large proportion of the population, particularly in the Caribbean islands, traces its ancestry to Africa as a consequence of the Atlantic slave trade during the XVI-XVIII centuries. As a result, sickle cell disease has been largely introduced in the region. Some Caribbean countries and/or territories, such as Jamaica and the French territories, initiated newborn screening (NBS) programs for sickle cell disease more than 20 years ago. They have demonstrated the major beneficial impact on mortality and morbidity resulting from early childhood care. However, similar programs have not been implemented in much of the region. This paper presents an update of the existing NBS programs and the prevalence of sickle cell disease in the Caribbean. It demonstrates the impact of the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia (CAREST) on the extension of these programs. The presented data illustrate the importance of advocacy in convincing policy makers of the feasibility and benefit of NBS for sickle cell disease when coupled to early care.

Indexed as

Caribbeannewborn screeningsickle cell disease

Identifiers

PMID33072965
PMCPMC7510201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.