Evidence map›Paper›PMID 33072885›Full record

ArticleEuropean stroke journal2020

Biomarkers and antithrombotic treatment in cervical artery dissection - Design of the TREAT-CAD randomised trial.

Christopher Traenka, Henrik Gensicke, Sabine Schaedelin, Andreas Luft, Marcel Arnold, Patrik Michel, Georg Kägi, Timo Kahles, Christian H Nolte, Lars Kellert and 8 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European stroke journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02046460 (Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection - TREAT-CAD), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02046460 phase3completednot on this map

Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection - TREAT-CAD

TypeinterventionalSponsorStefan EngelterRan2013 to 2019Enrolled194ConditionsCervical Artery DissectionArmsAcetylsalicylic acid, Vitamin K antagonist
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Cervical and intracranial artery dissections.Therapeutic advances in neurological disorders · 2021
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 3 countries.

Christopher TraenkaDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.ORCID https://orcid.org/0000-0002-7600-1005
Henrik GensickeDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Sabine SchaedelinDepartment of Clinical Research, Clinical Trial Unit, University Hospital Basel and University of Basel, Basel, Switzerland.
Andreas LuftDivision of Vascular Neurology and Neurorehabilitation, Department of Neurology, University Hospital of Zurich, Zurich, Switzerland.
Marcel ArnoldDepartment of Neurology, University Hospital Bern, Bern, Switzerland.
Patrik MichelStroke Center and Neurology Service, Department of Clinical Neurosciences, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Georg KägiDepartment of Neurology and Stroke Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Timo KahlesDepartment of Neurology and Stroke Center, Cantonal Hospital Aarau, Aarau, Switzerland.ORCID https://orcid.org/0000-0002-1569-6376
Christian H NolteCharité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Klinik und Hochschulambulanz für Neurologie, Berlin, Germany.ORCID https://orcid.org/0000-0001-5577-1775
Lars KellertDepartment of Neurology, Ludwig Maximilian University, Munich, Germany.
Sverre RosenbaumDepartment of Neurology, Bispebjerg Hospital, Copenhagen, Denmark.
Roman SztaizelDepartement of Neurology and Stroke Center, University Hospital Geneva and Medical School, Geneva, Switzerland.
Alex BrehmDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Christoph StippichDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Marios PsychogiosDepartment of Neuroradiology, Clinic of Radiology and Nuclear Medicine, University Hospital Basel, Basel, Switzerland.
Philippe LyrerDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
Stefan T EngelterDepartment of Neurology and Stroke Center, University Hospital Basel and University of Basel, Basel, Switzerland.
TREAT-CAD investigators
University of Basel · CHUniversity Hospital of Basel · CHBispebjerg Hospital · DKHumboldt-Universität zu Berlin · DEKantonsspital Aarau · CHLudwig-Maximilians-Universität München · DEUniversity Hospital of Bern · CHUniversity Hospital of Geneva · CHUniversity Hospital of Lausanne · CHUniversity Hospital of Zurich · CHUniversity of St.Gallen · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe type of antithrombotic treatment in cervical artery dissection patients is still a matter of debate. Most physicians prefer anticoagulants over antiplatelet agents for stroke prevention. However, this approach is not evidence-based and antiplatelets might be as safe and as effective. The 'Biomarkers and Antithrombotic Treatment in Cervical Artery Dissection' ('TREAT-CAD') trial (clinicaltrials.gov: NCT02046460) compares Aspirin to oral anticoagulants (vitamin K antagonists) with regard to efficacy and safety by using both clinical and imaging surrogate outcome measures. TREAT-CAD tests the hypothesis, that aspirin is as safe and effective as vitamin K antagonists. PATIENTS AND

methodsTREAD-CAD is a

resultsPrimary outcomes are assessed at 14 ± 10 days (magnetic resonance imaging and clinical examination) and at 90 ± 30 days (clinical examinations). The primary endpoint is a composite outcome measure - labelled DISCUSSION: After database closure, (i) central verification of cervical artery dissection diagnosis will be done by two experienced raters, (ii) adjudication of outcome events will be performed by independent adjudication committees, separately for clinical and imaging outcomes. The primary analysis will be done on the per protocol data set. The targeted sample size consists of 169 evaluable patients in the per protocol data set.

conclusionTREAT-CAD is testing the non-inferiority of Aspirin versus vitamin K antagonists treatment in patients with symptomatic cervical artery dissection by combined clinical and magnetic resonance imaging outcomes.

Indexed as

anticoagulantsantiplateletsCervical artery dissectionpreventionrandomised clinical trialstroke

Identifiers

PMID33072885
PMCPMC7538765
OpenAlexW3039578115

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.