Evidence map›Paper›PMID 33072860›Full record

ArticleAdvanced therapeutics2020

Emerging technologies for local cancer treatment.

Corrine Ying Xuan Chua, Jeremy Ho, Sandra Demaria, Mauro Ferrari, Alessandro Grattoni

Abstract read
In one paragraph

Article in Advanced therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Silk protein plastics for sustained and controlled drug release.International journal of pharmaceutics · 2026
    Article
  5. Tailoring the Release of Paclitaxel from Electrospun Nonwovens.International journal of molecular sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Corrine Ying Xuan ChuaDepartment of Nanomedicine, Houston Methodist Research Institute (HMRI), Houston, TX, 77030, USA.
Jeremy HoDepartment of Nanomedicine, Houston Methodist Research Institute (HMRI), Houston, TX, 77030, USA.
Sandra DemariaDepartment of Radiation Oncology, Weill Cornell Medicine, New York, NY, 10065, USA.
Mauro FerrariUniversity of Washington, Box 357630, H375 Health Science Building, Seattle, WA, 98195, USA.
Alessandro GrattoniDepartment of Nanomedicine, Houston Methodist Research Institute (HMRI), Houston, TX, 77030, USA.

Funding

Transport Oncophysics CoreU54CA210181 · NCI · METHODIST HOSPITAL RESEARCH INSTITUTE · PI CHANG, JENNY C-N, SHEN, HAIFA · 2016 to 2020
$9.3M
NCI NIH HHS U54 CA210181
6 · The paper itself

Abstract

The fundamental limitations of systemic therapeutic administration have prompted the development of local drug delivery platforms as a solution to increase effectiveness and reduce side effects. By confining therapeutics to the site of disease, local delivery technologies can enhance therapeutic index. This review highlights recent advances and opportunities in local drug delivery strategies for cancer treatment in addition to challenges that need to be addressed to facilitate clinical translation. The benefits of local cancer treatment combined with technological advancements and increased understanding of the tumor microenvironment, present a prime breakthrough opportunity for safer and more effective therapies.

Indexed as

cancer treatmentin situ deliveryintratumoral drug delivery technologiesintratumoral implantslocal controlled release

Identifiers

PMID33072860
PMCPMC7567411

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.