Evidence map›Paper›PMID 33072855›Full record

ArticleAdvanced materials technologies2020

Extrusion and Microfluidic-based Bioprinting to Fabricate Biomimetic Tissues and Organs.

Elham Davoodi, Einollah Sarikhani, Hossein Montazerian, Samad Ahadian, Marco Costantini, Wojciech Swieszkowski, Stephanie Willerth, Konrad Walus, Mohammad Mofidfar, Ehsan Toyserkani and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials technologies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

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  8. 3D-bioprinting for joint regeneration.Frontiers in bioengineering and biotechnology · 2026
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  10. 3D Bioprinting Strategies in Autoimmune Disease Models.International journal of molecular sciences · 2025
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elham DavoodiDepartment of Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Einollah SarikhaniCenter for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, CA 90095, USA.
Hossein MontazerianCenter for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, CA 90095, USA.
Samad AhadianCenter for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, CA 90095, USA.
Marco CostantiniBiomaterials Group, Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, 00-661 Warsaw, Poland.
Wojciech SwieszkowskiBiomaterials Group, Materials Design Division, Faculty of Materials Science and Engineering, Warsaw University of Technology, 00-661 Warsaw, Poland.
Stephanie WillerthDepartment of Mechanical Engineering, Division of Medical Sciences, University of Victoria, BC V8P 5C2, Canada.
Konrad WalusDepartment of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Mohammad MofidfarDepartment of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.
Ehsan ToyserkaniDepartment of Mechanical and Mechatronics Engineering, University of Waterloo, Waterloo, ON N2L 3G1, Canada.
Ali KhademhosseiniCenter for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, CA 90095, USA.
Nureddin AshammakhiCenter for Minimally Invasive Therapeutics (C-MIT), University of California, Los Angeles, CA 90095, USA.

Funding

3D printed muscle-bone organ implant for treating large injuriesR01AR073135 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DOKMECI, MEHMET REMZI, JANG, HAE LIN · 2018 to 2022
$2.2M
Rapid 3D bioprinting of biomimetic vascularized tissue constructsR01EB021857 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHEN, SHAOCHEN, DOKMECI, MEHMET REMZI · 2016 to 2019
$2.1M
NIAMS NIH HHS R01 AR073135NIBIB NIH HHS R01 EB021857
6 · The paper itself

Abstract

Next generation engineered tissue constructs with complex and ordered architectures aim to better mimic the native tissue structures, largely due to advances in three-dimensional (3D) bioprinting techniques. Extrusion bioprinting has drawn tremendous attention due to its widespread availability, cost-effectiveness, simplicity, and its facile and rapid processing. However, poor printing resolution and low speed have limited its fidelity and clinical implementation. To circumvent the downsides associated with extrusion printing, microfluidic technologies are increasingly being implemented in 3D bioprinting for engineering living constructs. These technologies enable biofabrication of heterogeneous biomimetic structures made of different types of cells, biomaterials, and biomolecules. Microfluiding bioprinting technology enables highly controlled fabrication of 3D constructs in high resolutions and it has been shown to be useful for building tubular structures and vascularized constructs, which may promote the survival and integration of implanted engineered tissues. Although this field is currently in its early development and the number of bioprinted implants is limited, it is envisioned that it will have a major impact on the production of customized clinical-grade tissue constructs. Further studies are, however, needed to fully demonstrate the effectiveness of the technology in the lab and its translation to the clinic.

Indexed as

bioinkbiomimeticBioprintingmicrofluidicstissue engineering

Identifiers

PMID33072855
PMCPMC7567134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.