Evidence map›Paper›PMID 33072817›Full record

ArticleCogent psychology2020

Antecedents of Purpose in Life: Evidence from A Lagged Exposure-Wide Analysis.

Ying Chen, Eric S Kim, Alexandra E Shields, Tyler J VanderWeele

Abstract read
In one paragraph

Article in Cogent psychology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Daily Activities and Purpose in Life.International journal of wellbeing · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Exploring novel determinants of exercise behavior: a lagged exposure-wide approach.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025
    Article
  8. Important Correlates of Purpose in Life in a Diverse Population-Based Cohort: A Machine Learning Approach.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Article
  9. Biopsychosocial Factors That Influence the Purpose in Life among Working Adults and Retirees.International journal of environmental research and public health · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Role of Libraries in Human Flourishing: Adolescents' Motivational Orientation for Occupation.International journal of environmental research and public health · 2021
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ying ChenHuman Flourishing Program, Harvard Institute for Quantitative Social Science, Cambridge, MA, USA.
Eric S KimHuman Flourishing Program, Harvard Institute for Quantitative Social Science, Cambridge, MA, USA.
Alexandra E ShieldsDepartment of Medicine, Harvard Medical School, Boston, MA; Harvard/MGH Center on Genomics, Vulnerable Populations, and Health Disparities, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.
Tyler J VanderWeeleHuman Flourishing Program, Harvard Institute for Quantitative Social Science, Cambridge, MA, USA.

Funding

Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Premonopausal Hormone Levels and Risk of Breast CancerR01CA067262 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HANKINSON, SUSAN E · 2002 to 2011
$11.9M
Theory and methods for mediation and interactionR01CA222147 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TCHETGEN TCHETGEN, ERIC JOEL, VANDERWEELE, TYLER · 2018 to 2022
$2.1M
Characterizing the mechanisms behind the association between purpose in life and healthK99AG055696 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI KIM, ERIC · 2018 to 2019
$256k
NCI NIH HHS R01 CA067262NCI NIH HHS R01 CA222147NCI NIH HHS U01 CA176726NIA NIH HHS K99 AG055696
6 · The paper itself

Abstract

Potential antecedents to having a sense of purpose in life remain understudied. As researchers begin contemplating purpose as a promising target of public health intervention, it is critical to identify its antecedents. Using prospective data from the Nurses' Health Study II (2009-2016; N ranged from 3,905 to 4,189), this study evaluated a wide range of potential antecedents of purpose, including: psychosocial well-being, psychological distress, employment characteristics, lifestyle, and physical health factors. In separate regression models we regressed purpose in life on each candidate antecedent. In each model, we adjusted for the prior value of purpose, prior values of all exposure variables, and various other covariates simultaneously. Bonferroni correction was used to correct for multiple testing. The results suggested that positive affect and the number of close relatives were each associated with higher purpose (e.g., β=0.14, 95% CI: 0.11, 0.17 for positive affect). Several psychological distress indicators were inversely associated with purpose, including depressive symptoms, anxiety symptoms, loneliness, and hopelessness (e.g., β=-0.16, 95% CI: -0.19, -0.13 for depressive symptoms). There was also some evidence suggesting that fewer close friends, living alone, and unemployment/retirement were associated with lower purpose. There was, however, little evidence that health behaviors or physical health were associated with subsequent purpose. This study extends the literature by providing longitudinal evidence with rigorous analytic methodologies, and by considering a wide range of potential antecedents of purpose including some that have seldom been examined previously.

Indexed as

antecedentshealth and well-beinglagged exposure-wide analysismid-lifepsychological well-beingpurpose in life

Identifiers

PMID33072817
PMCPMC7560975

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.