Evidence map›Paper›PMID 33072807›Full record

ArticleOpen forum infectious diseases2020

Child HIV Exposure and CMV Seroprevalence in Botswana: No Associations With 24-Month Growth and Neurodevelopment.

Natasha O Moraka, Sikhulile Moyo, Christiana Smith, Maryanne Ibrahim, Gloria Mayondi, Jean Leidner, Kathleen M Powis, Adam R Cassidy, Betsy Kammerer, Gbolahan Ajibola and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 3 countries.

Natasha O MorakaResearch Laboratory Department, The Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Sikhulile MoyoResearch Laboratory Department, The Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Christiana SmithPediatric Infectious Diseases, University of Colorado Denver, Denver, Colorado, USA.ORCID 0000-0002-4611-6477
Maryanne IbrahimDepartment of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Gloria MayondiResearch Laboratory Department, The Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Jean LeidnerGoodtables Data Consulting, Norman, Oklahoma, USA.
Kathleen M PowisResearch Laboratory Department, The Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Adam R CassidyDepartment of Psychiatry, Boston Children's Hospital, Boston, Massachusetts, USA.
Betsy KammererDepartment of Psychiatry, Boston Children's Hospital, Boston, Massachusetts, USA.
Gbolahan AjibolaResearch Laboratory Department, The Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Paige L WilliamsDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Adriana WeinbergPediatric Infectious Diseases, University of Colorado Denver, Denver, Colorado, USA.
Rosemary MusondaResearch Laboratory Department, The Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Roger ShapiroResearch Laboratory Department, The Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Simani GaseitsiweResearch Laboratory Department, The Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Shahin LockmanResearch Laboratory Department, The Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana.
Harvard University · USBoston Children's Hospital · USBotswana Harvard AIDS Institute Partnership · BWUniversity of Colorado Denver · USBaylor College of Medicine · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USStellenbosch University · ZA

Funding

Training in HIV Genomics, Treatment, and Cure Research in BotswanaD43TW009610 · FIC · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · PI SHAHIN LOCKMAN, Joseph Moeketsi Makhema · 2013 to 2026
$4.4M
Effects of HIV and ARV Exposure on Child Health and Neurodevelopment in Botswana.R01MH087344 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI KAMMERER, BETSY, LOCKMAN, SHAHIN · 2009 to 2013
$2.9M
Mentoring in Patient-Oriented HIV Research in the Era of Universal ARTK24AI131928 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAHIN LOCKMAN · 2017 to 2026
$1.9M
Expansion of research and mentoring to improve birth outcomes and treatment outcomes among HIV-affected children in BotswanaK24AI131924 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Roger L Shapiro · 2018 to 2026
$1.6M
FIC NIH HHS D43 TW009610NIAID NIH HHS K24 AI131924NIAID NIH HHS K24 AI131928NIMH NIH HHS R01 MH087344Wellcome Trust
6 · The paper itself

Abstract

backgroundWe sought to identify predictors of child cytomegalovirus (CMV) infection overall and by maternal HIV status and to assess associations of child CMV status with growth and neurodevelopmental outcomes at 24 months of age in Botswana.

methodsData and samples were used from the Botswana-based observational Tshipidi study (2010-2014), enrolling pregnant women living with and without HIV and following their infants through 2 years of age. Child plasma samples were tested at 18 months of age for anti-CMV immunoglobulin G (IgG). Associations were assessed between detectable anti-CMV IgG and growth (using the World Health Organization Child Growth Standards) and neurodevelopment (using the Bayley Scales of Infant and Toddler Development III and the Developmental Milestones Checklist) at 24 months of age.

resultsOf 317 children, 215 (68%) had detectable anti-CMV IgG at 18 months of age. Comparatively, 83% (n = 178) of HIV-unexposed uninfected (HUU) children had positive CMV serology vs 47% (n = 139) of HIV-exposed uninfected (HEU) children (

conclusionsWe observed high CMV seropositivity in 18-month-old children in Botswana, with higher seropositivity among breastfed (HUU) children. Positive CMV serostatus was not associated with 24-month child growth or neurodevelopmental outcomes, with the exception of smaller head circumference among HUU CMV-positive children.

Indexed as

anthropometricsBotswanachildrencytomegalovirusHIV-exposed uninfectedHIV-unexposed uninfectedneurodevelopment

Identifiers

PMID33072807
PMCPMC7539691
OpenAlexW2981558012

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.