ArticleFrontiers in cell and developmental biology2020
Presence/Absence and Specific Location of Resident CD34+ Stromal Cells/Telocytes Condition Stromal Cell Development in Repair and Tumors.
Article in Frontiers in cell and developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Npc1 gene mutation impairs multilineage differentiation potential of hepatic telocytes in murine models.Cell biology and toxicology · 2025Article
- Skin Telocyte Secretome as Conditioned Medium Prevents Profibrotic Differentiation of Skin Fibroblasts into Myofibroblasts.International journal of molecular sciences · 2025Article
- Telocytes/CD34+ Stromal Cells in the Normal, Hyperplastic, and Adenomatous Human Parathyroid Glands.International journal of molecular sciences · 2023Article
- Sequential histologic evolution of gallbladder inflammation in acute cholecystitis over the first 10 days after onset of symptoms.Journal of hepato-biliary-pancreatic sciences · 2023Article
- Tumour-derived exosomal lncRNA SNHG16 induces telocytes to promote metastasis of hepatocellular carcinoma via the miR-942-3p/MMP9 axis.Cellular oncology (Dordrecht, Netherlands) · 2023Article
- Scleroderma-like Impairment in the Network of Telocytes/CD34International journal of molecular sciences · 2021Article
- Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin.International journal of molecular sciences · 2021Review
- Decreased m6A Modification of CD34/CD276(B7-H3) Leads to Immune Escape in Colon Cancer.Frontiers in cell and developmental biology · 2021Article
- Telocytes/CD34+ Stromal Cells in Pathologically Affected White Adipose Tissue.International journal of molecular sciences · 2020Review
- Intussusceptive Angiogenesis and Peg-Socket Junctions between Endothelial Cells and Smooth Muscle Cells in Early Arterial Intimal Thickening.International journal of molecular sciences · 2020Article
- Telocytes inside of the peripheral nervous system - a 3D endoneurial network and putative role in cell communication.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD34+ stromal cells/telocytes (CD34+SCs/TCs) can have a role as mesenchymal precursor cells. Our objective is to assess whether the myofibroblastic stromal cell response in repair and in desmoplastic reactions in tumors depend on the presence or absence of resident CD34+SCs/TCs in specific regions/layers of an organ and on the location of their possible subpopulations. For this purpose, using conventional and immunohistochemical procedures, we studied specimens of (a) acute cholecystitis, with early repair phenomena (n: 6), (b) surgically resected segments of colon tattooed with India ink during previous endoscopic removal of malignant polyps, with macrophage infiltration and stromal cell reaction (n: 8) and (c) infiltrative adenocarcinomas of colon, with desmoplastic reaction (n: 8). The results demonstrated (a) stromal myofibroblastic reaction during repair and tumor desmoplasia in most regions in which resident CD34+SCs/TCs are present, (b) absence of stromal myofibroblastic reaction during repair in the mucosa of both organs in which resident CD34+SCs/TCs are absent and (c) permanence of CD34+SCs/TCs as such, without myofibroblastic response, in smooth muscle fascicles, nerves, and Meissner and Auerbach plexuses, in which the CD34+SCs/TCs mainly undergo reactive phenomena. Therefore, the development of activated αSMA+ myofibroblasts in these conditions requires the presence of resident CD34+SCs/TCs and depends on their location. In conclusion, the facts support the hypotheses that CD34+SCs/TCs participate in the origin of myofibroblasts during repair and tumor stroma formation, and that there is a heterogeneous population of resident CD34+SCs/TCs with different roles.
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