Evidence map›Paper›PMID 33072529›Full record

ArticleMethodsX2020

A radiolabeled drug tracing method to study neurotrophin-3 retention and distribution in the cochlea after nano-based local delivery.

Patrick Lam, Niliksha Gunewardene, Yutian Ma, Frank Caruso, Trung Nguyen, Brianna Flynn, Andrew K Wise, Rachael T Richardson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MethodsX, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Patrick LamBionics Institute, East Melbourne, Victoria 3002, Australia.
Niliksha GunewardeneBionics Institute, East Melbourne, Victoria 3002, Australia.
Yutian MaBionics Institute, East Melbourne, Victoria 3002, Australia.
Frank CarusoARC Centre of Excellence in Convergent Bio-Nano Science and Technology, and the Department of Chemical Engineering, University of Melbourne, Parkville, Victoria 3010, Australia.
Trung NguyenBionics Institute, East Melbourne, Victoria 3002, Australia.
Brianna FlynnBionics Institute, East Melbourne, Victoria 3002, Australia.
Andrew K WiseBionics Institute, East Melbourne, Victoria 3002, Australia.
Rachael T RichardsonBionics Institute, East Melbourne, Victoria 3002, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery into the cochlea has shown great potential in protecting and repairing the sensory cells important for hearing. However, delivery of these factors into the inner ear at therapeutic levels over a sustained period of time has remained a challenge restricting clinical translation. We have developed a method to test the pharmacokinetics of neurotrophin released from porous silica particles called 'supraparticles' that can provide sustained release of neurotrophins to the inner ear.•This report describes a radiolabeling method to examine neurotrophin retention and distribution in the cochlea. The neurotrophin was labeled with a radioactive tracer (iodine 125:

Indexed as

CochleaDrug deliveryHearing lossInner earNanoparticlesNeurotrophinsProtein therapy

Identifiers

PMID33072529
PMCPMC7549113

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.