ReviewThe World Allergy Organization journal2020
Food protein-induced allergic proctocolitis in infants: Literature review and proposal of a management protocol.
Review in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Article
- Are Management Strategies Associated with Tolerance Acquisition in Infants with Cow's Milk-Induced Allergic Proctocolitis?Journal of clinical medicine · 2026Article
- Diagnosis and treatment of neonatal gastrointestinal diseases in extremely premature infants using ultrathin colonoscopy.Pediatric research · 2026Article
- Clinical characteristics, prognosis, and risk factors for tolerance development in food protein-induced allergic proctocolitis: a retrospective cohort study.Translational pediatrics · 2026Article
- Strain-level microbial signatures and inferred functional alterations in infants with food protein-induced allergic proctocolitis.Genome medicine · 2026Article
- Mucous Stools in Infancy as an Early Marker of the Atopic March: A Four-Year Cohort Study of Respiratory Atopy Risk.Children (Basel, Switzerland) · 2026Article
- Evaluating the effectiveness of elimination diet in infants with CMP-induced allergic proctocolitis using CoMiSS.Pediatric research · 2026Article
- Diagnosis and Management of Food Protein-Induced Allergic Proctocolitis.Current gastroenterology reports · 2025Review
- High Rate of Positive Fecal Occult Blood Test in Healthy Infants: A Nested Case-control Study.Journal of translational gastroenterology · 2025Article
- Prevalence Clinical Syndromes and Outcomes of Cow's Milk Allergy in Children: A Four-Year Follow-Up.Nutrients · 2025Article
- Analysis of Clinical Characteristics of Refractory Food Protein-Induced Allergic Proctocolitis.Children (Basel, Switzerland) · 2025Article
- Allergic proctocolitis: Evaluation and management.Journal of food allergy · 2025Review
- Sensitization to common food allergens in infants with food protein-induced allergic proctocolitis: A prospective study.Asia Pacific allergy · 2025Article
- Observational
- [Colonoscopy in infants: procedure and disease spectrum analysis of 184 cases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Review
- Gut Microbiota Differences in Infants with Cow-Milk-Induced Allergic Proctocolitis: A Comparative Cross-Sectional Study.Children (Basel, Switzerland) · 2025Article
- Individualized Nutritional Counseling Closes Growth and Nutrition Gaps in Infants With Food Protein-Induced Allergic Proctocolitis: 6-Month Follow-Up Study.Food science & nutrition · 2025Article
- The Immunological Mechanisms Involved in the Pathophysiology of Allergic Proctocolitis.Children (Basel, Switzerland) · 2025Article
- Cow's Milk Allergy in Breastfed Infants: What We Need to Know About Mechanisms, Management, and Maternal Role.Nutrients · 2025Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Food protein-induced allergic proctocolitis (FPIAP) is a condition characterized by inflammatory changes in the distal colon in response to one or more foreign food proteins because of immune-mediated reactions. FPIAP prevalence estimates range widely from 0.16% in healthy children and 64% in patients with blood in stools. In clinical practice, FPIAP is diagnosed when patients respond positively to the elimination of a suspected triggering food allergen. Nevertheless, significant proportions of infants get misdiagnosed with IgE mediated allergy and undergo unnecessary dietary changes. Diagnosis is based on clinical symptoms, a good response to an allergen-free diet and the recurrence of symptoms during the "allergy challenge test". Sometimes clinical features may be non-specific and the etiology of rectal bleeding in childhood may be heterogeneous. Therefore, it is crucial to exclude a variety of other possible causes of rectal bleeding in the pediatric age group, including infection, anal fissure, intestinal intussusception and, in infants, necrotizing enterocolitis and very early onset inflammatory bowel disease. The diagnostic workup includes in those cases invasive procedures such as sigmoidoscopy and colonoscopy with biopsies. The high prevalence of FPIAP contrasts with the lack of known information about the pathogenesis of this condition. For this reason and due to the absence of a review of the evidence, a literature review appears necessary to clarify some aspects of allergic colitis. The aim of the review is to fill this gap and to lay the foundations for a subsequent evidence-based approach to the condition.
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