Evidence map›Paper›PMID 33072075›Full record

ArticleFrontiers in immunology2020

Transcriptome Profiling of Human Monocyte-Derived Macrophages Upon CCL2 Neutralization Reveals an Association Between Activation of Innate Immune Pathways and Restriction of HIV-1 Gene Expression.

Daniela Angela Covino, Karolina Elżbieta Kaczor-Urbanowicz, Jing Lu, Maria Vincenza Chiantore, Gianna Fiorucci, Maria Fenicia Vescio, Laura Catapano, Cristina Purificato, Clementina Maria Galluzzo, Roberta Amici and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Daniela Angela CovinoNational Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Karolina Elżbieta Kaczor-UrbanowiczUCLA Section of Oral Biology, Division of Oral Biology & Medicine, Center for Oral and Head/Neck Oncology Research, Center for the Health Sciences, UCLA School of Dentistry, University of California at Los Angeles, Los Angeles, CA, United States.
Jing LuUCLA Institute for Quantitative and Computational Biosciences, University of California at Los Angeles, Los Angeles, CA, United States.
Maria Vincenza ChiantoreDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Gianna FiorucciDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Maria Fenicia VescioDepartment of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.
Laura CatapanoNational Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Cristina PurificatoNational Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Clementina Maria GalluzzoNational Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Roberta AmiciNational Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Mauro AndreottiNational Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Maria Cristina GauzziNational Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Matteo PellegriniUCLA Institute for Quantitative and Computational Biosciences, University of California at Los Angeles, Los Angeles, CA, United States.
Laura FantuzziNational Center for Global Health, Istituto Superiore di Sanità, Rome, Italy.
Istituto Superiore di Sanità · ITQB3 · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages are key targets of human immunodeficiency virus type 1 (HIV-1) infection and main producers of the proinflammatory chemokine CC chemokine ligand 2 (CCL2), whose expression is induced by HIV-1 both

Indexed as

Gene Expression ProfilingImmunity, InnateAntibodies, NeutralizingAntibody SpecificityCells, CulturedChemokine CCL2Cytidine DeaminaseDatasets as TopicGene Expression Regulation, ViralHIV-1HumansMacrophagesMicroRNAsMolecular Sequence AnnotationNF-kappa BProteinsAntibodies, NeutralizingAPOBEC3A protein, humanCCL2 protein, humanChemokine CCL2Cytidine DeaminaseMicroRNAsMIRN155 microRNA, humanNF-kappa BProteinsRNA, ViralCCL2 (MCP-1)HIV-1innate responsemacrophagemiR-155NF-κBRNA-sequencingtranscriptional profile

Identifiers

PMID33072075
PMCPMC7531389
OpenAlexW3087685115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.