Evidence map›Paper›PMID 33072063›Full record

ReviewFrontiers in immunology2020

Molecular Insights Into Regulatory T-Cell Adaptation to Self, Environment, and Host Tissues: Plasticity or Loss of Function in Autoimmune Disease.

Cheryl Y Brown, Timothy Sadlon, Christopher M Hope, Ying Y Wong, Soon Wong, Ning Liu, Holly Withers, Katherine Brown, Veronika Bandara, Batjargal Gundsambuu and 6 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. CD25Frontiers in immunology · 2026
    Article
  4. Chimerism-Mediated Tolerance in Intestinal Transplantation.Gastroenterology clinics of North America · 2024
    Review
  5. Article
  6. Review
  7. Influence of Age, Gender, Frailty, and Body Mass Index on Serum IL-17A Levels in Mature Type 2 Diabetic Patients.Medical science monitor : international medical journal of experimental and clinical research · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. The role of IL-33/ST2 signaling in the tumor microenvironment and Treg immunotherapy.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
  12. Review
  13. The Role of Exposomes in the Pathophysiology of Autoimmune Diseases II: Pathogens.Pathophysiology : the official journal of the International Society for Pathophysiology · 2022
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Cheryl Y BrownMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Timothy SadlonMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Christopher M HopeWomen's and Children's Health Network, North Adelaide, SA, Australia.
Ying Y WongMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Soon WongMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Ning LiuBioinformatics Hub, University of Adelaide, Adelaide, SA, Australia.
Holly WithersMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Katherine BrownMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Veronika BandaraMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Batjargal GundsambuuMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Stephen PedersonBioinformatics Hub, University of Adelaide, Adelaide, SA, Australia.
James BreenBioinformatics Hub, University of Adelaide, Adelaide, SA, Australia.
Sarah Anne RobertsonMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Alistair ForrestQEII Medical Centre and Centre for Medical Research, Harry Perkins Institute of Medical Research, Murdoch, WA, Australia.
Marc BeyerGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Simon Charles BarryMolecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
University of Adelaide · AUWomen's and Children's Health Network · AUGerman Center for Neurodegenerative Diseases · DEHarry Perkins Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There has been much interest in the ability of regulatory T cells (Treg) to switch function

Indexed as

Adaptation, PhysiologicalAnimalsAutoimmune DiseasesCell PlasticityChromatin Assembly and DisassemblyDisease SusceptibilityEnergy MetabolismEnvironmentGene Expression RegulationHumansImmunity, CellularRegulatory Sequences, Nucleic AcidRNA, UntranslatedT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsRNA, Untranslatedgene regulationgenetic risk of diseaseT-cell fateT-cell plasticityTreg FOXP3

Identifiers

PMID33072063
PMCPMC7533603
OpenAlexW3093272943

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.