ArticleFrontiers in neuroanatomy2020
3D Exploration of the Brainstem in 50-Micron Resolution MRI.
Article in Frontiers in neuroanatomy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Investigations into the anatomical location, physiological function, clinical implications, and significance of the nucleus of Perlia.Acta neurologica Belgica · 2024Pooled it
- Anatomically constrained and curated cerebellar tractography (ACCURAT): an open framework and a pathway-specific neuroanatomical reference.bioRxiv : the preprint server for biology · 2026Article
- The human olfactory amygdala: Anatomical connections between the olfactory bulb and amygdala subregions.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Combined T1-weighted MRI and diffusion MRI tractography of paraventricular, locus coeruleus, and dorsal vagal complex connectivity in brainstem-hypothalamic nuclei.Journal of biological methods · 2024Article
- Ultrahigh-resolution 7-Tesla anatomic magnetic resonance imaging and diffusion tensor imaging ofFrontiers in human neuroscience · 2024Article
- ProbaStem, a pipeline towards the first high-resolution probabilistic atlas of the whole human brainstem.Brain structure & function · 2024Article
- A Novel Human Brainstem Map Based on True-Color Sectioned Images.Journal of Korean medical science · 2023Article
- Changes in respiratory structure and function after traumatic cervical spinal cord injury: observations from spinal cord and brain.Frontiers in neurology · 2023Review
- Anatomically curated segmentation of human subcortical structures in high resolution magnetic resonance imaging: An open science approach.Frontiers in neuroanatomy · 2022Article
- Structural Connectivity of Human Inferior Colliculus Subdivisions UsingFrontiers in neuroscience · 2022Article
- Microstructural alterations in medial forebrain bundle are associated with interindividual pain sensitivity.Human brain mapping · 2021Article
- A Topographic Atlas of the Human Brainstem in the Ponto-Mesencephalic Junction Plane.Frontiers in neuroanatomy · 2021Article
- Looking beneath the surface: the importance of subcortical structures in frontotemporal dementia.Brain communications · 2021Review
- The Distributional Characteristics of Multiple Sclerosis Lesions on Quantitative Susceptibility Mapping and Their Correlation With Clinical Severity.Frontiers in neurology · 2021Article
- 3D Exploration of the Brainstem in 50-Micron Resolution MRI.Frontiers in neuroanatomy · 2020Article
Corrections and comments
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Authors and funding
15 authors at 8 institutions in 3 countries.
Funding
Abstract
The brainstem, a structure of vital importance in mammals, is currently becoming a principal focus in cognitive, affective, and clinical neuroscience. Midbrain, pontine and medullary structures serve as the conduit for signals between the forebrain and spinal cord, are the epicenter of cranial nerve-circuits and systems, and subserve such integrative functions as consciousness, emotional processing, pain, and motivation. In this study, we parcellated the nuclear masses and the principal fiber pathways that were visible in a high-resolution T2-weighted MRI dataset of 50-micron isotropic voxels of a postmortem human brainstem. Based on this analysis, we generated a detailed map of the human brainstem. To assess the validity of our maps, we compared our observations with histological maps of traditional human brainstem atlases. Given the unique capability of MRI-based morphometric analysis in generating and preserving the morphology of 3D objects from individual 2D sections, we reconstructed the motor, sensory and integrative neural systems of the brainstem and rendered them in 3D representations. We anticipate the utilization of these maps by the neuroimaging community for applications in basic neuroscience as well as in neurology, psychiatry, and neurosurgery, due to their versatile computational nature in 2D and 3D representations in a publicly available capacity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.