Evidence map›Paper›PMID 33071711›Full record

ArticleAdvanced functional materials2020

Biodegradable nanofibrous temperature-responsive gelling microspheres for heart regeneration.

Chao Zhao, Shuo Tian, Qihai Liu, Kemao Xiu, Ienglam Lei, Zhong Wang, Peter X Ma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 72 citations in OpenAlex.

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  17. Poly(Gels (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Chao ZhaoDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109.
Shuo TianDepartment of Cardiac Surgery, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48109.
Qihai LiuDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109.
Kemao XiuDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109.
Ienglam LeiDepartment of Cardiac Surgery, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48109.
Zhong WangDepartment of Cardiac Surgery, Frankel Cardiovascular Center, University of Michigan, Ann Arbor, MI 48109.
Peter X MaDepartment of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109.
University of Michigan · US

Funding

Two-stage miRNA delivering scaffolds for patient-originated cells to regenerate blood vesselsR01HL136231 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHEN, YUQING EUGENE · 2017 to 2020
$3.0M
Regenerating Blood Vessels Using iPS CellsR01HL114038 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X · 2013 to 2016
$2.1M
Epigenetic control of multipotent cardiac progenitor cell differentiationR01HL109054 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WANG, ZHONG · 2012 to 2016
$1.9M
Nanofibrous self-gelling microspheres for heart regenerationR01HL139735 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MA, PETER X, WANG, ZHONG · 2019 to 2022
$1.6M
NHLBI NIH HHS R01 HL109054NHLBI NIH HHS R01 HL114038NHLBI NIH HHS R01 HL136231NHLBI NIH HHS R01 HL139735
6 · The paper itself

Abstract

Myocardial infarction (heart attack) is the number one killer of heart patients. Existing treatments for heart attack do not address the underlying problem of cardiomyocyte (CM) loss and cannot regenerate the myocardium. Introducing exogenous cardiac cells is required for heart regeneration due to the lack of resident progenitor cells and very limited proliferative potential of adult CMs. Poor retention of transplanted cells is the critical bottleneck of heart regeneration. Here, we report the invention of a poly(l-lactic acid)-

Indexed as

Block copolymercell transplantationheart regenerationhydrogelnanofiber

Identifiers

PMID33071711
PMCPMC7567402
OpenAlexW3011631329

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.