ArticleReproductive medicine and biology2020
Cutting the ovarian surface improves the responsiveness to exogenous hormonal treatment in aged mice.
Article in Reproductive medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Establishment of an in vitro implantation model using a newly developed mouse endometrial organoid.Development (Cambridge, England) · 2025Article
- The stromal microenvironment and ovarian aging: mechanisms and therapeutic opportunities.Journal of ovarian research · 2023Review
- Accumulation of senescent cells in the stroma of aged mouse ovary.The Journal of reproduction and development · 2023Article
- Facilitation of Ovarian Response by Mechanical Force-Latest Insight on Fertility Improvement in Women with Poor Ovarian Response or Primary Ovarian Insufficiency.International journal of molecular sciences · 2023Review
- A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotypes.Reproductive medicine and biology · 2022Article
- Effect of samul-tang on female fertility via RAS signaling pathway in ovaries of aged mice.Aging · 2021Article
- Cutting the ovarian surface improves the responsiveness to exogenous hormonal treatment in aged mice.Reproductive medicine and biology · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeOvarian vascular abnormality and ovarian fibrosis are observed in the low responder patients and aging mice. Vascularization and fibrosis are regulated by injury-repair system, such as wound. Thus, in this study, the authors tried to investigate the effect of the surgical treatment to ovarian surface with cutting on the functions of ovary in aging mouse model, gc
methodThe ovarian surface of gc
resultOvarian fibrosis disappeared at 7 days after surgery. With the abrogation of fibrosis, the blood vessels were fluently observed around the follicles, and the follicular development was re-started. The responses against exogenous hormone were recovered at 21 days after the surgery, and estrous cycle and delivery were also recovered by the surgery and the fertility was maintained for 3 months.
conclusionThis cutting method of ovarian surface becomes a good option against low responder patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.