Evidence map›Paper›PMID 33071423›Full record

ArticleInverse problems2020

Fisher information analysis of list-mode SPECT emission data for joint estimation of activity and attenuation distribution.

Ashequr Rahman, Yansong Zhu, Eric Clarkson, Matthew A Kupinski, Eric C Frey, Abhinav K Jha

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inverse problems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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  5. Deep-learning-based methods of attenuation correction for SPECT and PET.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
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  9. Article
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  11. Artificial Intelligence in Nuclear Medicine: Opportunities, Challenges, and Responsibilities Toward a Trustworthy Ecosystem.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Article
  12. Cross-vender, cross-tracer, and cross-protocol deep transfer learning for attenuation map generation of cardiac SPECT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022
    Article
  13. Article
  14. A physics and learning-based transmission-less attenuation compensation method for SPECT.Proceedings of SPIE--the International Society for Optical Engineering · 2021
    Article
  15. Task-based assessment of binned and list-mode SPECT systems.Proceedings of SPIE--the International Society for Optical Engineering · 2021
    Article
  16. Article
  17. Deep learning-based attenuation map generation for myocardial perfusion SPECT.European journal of nuclear medicine and molecular imaging · 2020
    Article
  18. A LIST-MODE OSEM-BASED ATTENUATION AND SCATTER COMPENSATION METHOD FOR SPECT.Proceedings. IEEE International Symposium on Biomedical Imaging · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Ashequr RahmanDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Yansong ZhuDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
Eric ClarksonCollege of Optical Sciences, University of Arizona, Tucson AZ, USA.
Matthew A KupinskiCollege of Optical Sciences, University of Arizona, Tucson AZ, USA.
Eric C FreyDepartment of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA.
Abhinav K JhaDepartment of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA.
University of Arizona · USWashington University in St. Louis · USJohns Hopkins University · USUniversity of British Columbia · CA

Funding

SPECT Imaging and Parallel ComputingR01EB000803 · NIBIB · UNIVERSITY OF ARIZONA · PI CAUCCI, LUCA · 2012 to 2020
$4.2M
End-to-End Optimization of SPECT Instrumentation, Acquisition, and ReconstructionR01EB016231 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI FREY, ERIC C., LINKS, JONATHAN M. · 2013 to 2016
$1.4M
Transmission-less attenuation and scatter compensation in myocardial perfusion SPECT with list-mode dataR21EB024647 · NIBIB · WASHINGTON UNIVERSITY · PI JHA, ABHINAV K · 2018 to 2019
$430k
NIBIB NIH HHS R01 EB000803NIBIB NIH HHS R01 EB016231NIBIB NIH HHS R21 EB024647
6 · The paper itself

Abstract

The potential to perform attenuation and scatter compensation (ASC) in single-photon emission computed tomography (SPECT) imaging without a separate transmission scan is highly significant. In this context, attenuation in SPECT is primarily due to Compton scattering, where the probability of Compton scatter is proportional to the attenuation coefficient of the tissue and the energy of the scattered photon and the scattering angle are related. Based on this premise, we investigated whether the SPECT scattered-photon data acquired in list-mode (LM) format and including the energy information can be used to estimate the attenuation map. For this purpose, we propose a Fisher-information-based method that yields the Cramer-Rao bound (CRB) for the task of jointly estimating the activity and attenuation distribution using only the SPECT emission data. In the process, a path-based formalism to process the LM SPECT emission data, including the scattered-photon data, is proposed. The Fisher information method was implemented on NVIDIA graphics processing units (GPU) for acceleration. The method was applied to analyze the information content of SPECT LM emission data, which contains up to first-order scattered events, in a simulated SPECT system with parameters modeling a clinical system using realistic computational studies with 2-D digital synthetic and anthropomorphic phantoms. The method was also applied to LM data containing up to second-order scatter for a synthetic phantom. Experiments with anthropomorphic phantoms simulated myocardial perfusion and dopamine transporter (DaT)-Scan SPECT studies. The results show that the CRB obtained for the attenuation and activity coefficients was typically much lower than the true value of these coefficients. An increase in the number of detected photons yielded lower CRB for both the attenuation and activity coefficients. Further, we observed that systems with better energy resolution yielded a lower CRB for the attenuation coefficient. Overall, the results provide evidence that LM SPECT emission data, including the scattered photons, contains information to jointly estimate the activity and attenuation coefficients.

Indexed as

Attenuation compensationFisher informationJoint reconstructionList-mode dataScatteringSPECT

Identifiers

PMID33071423
PMCPMC7561050
OpenAlexW2811395286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.