ArticleBrain and behavior2020
What it takes to be at the top: The interrelationship between chronic social stress and social dominance.
Article in Brain and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 29 citations in OpenAlex.
- Social hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice.iScience · 2026Article
- Region-specific neural activity changes and hierarchical instability following social isolation.iScience · 2026Article
- New neurons flatten social hierarchies.Scientific reports · 2026Article
- Very long chain sphingolipids govern brain myelination by regulating oligodendrocyte differentiation and membrane microdomain integrity.Journal of translational medicine · 2026Article
- Social hierarchy and resilience affect stress-induced PTSD via Uba7 gene expression and subsequent inflammation in microglia of the mPFC.Molecular psychiatry · 2026Article
- Social rank and social environment combinedly affect REM sleep in mice.Scientific reports · 2026Article
- Opposing roles of microglial and macrophagic C3ar1 signaling in stress-induced synaptic and behavioral changes.Molecular psychiatry · 2025Article
- Dopaminergic neurons in the dorsal raphe nucleus may modulate social dominance in mice.Zoological research · 2025Article
- Characterization of Neurensin-2 knockout mice: insights into stress-resilience mechanisms.Translational psychiatry · 2025Article
- Oxytocin reduces asymmetries in dominance relationships between pairs of captive female lions.Scientific reports · 2025Article
- A functionalist approach to social status in social animals, humans and the dog-human community. The prestige-based social system hypothesis.Biologia futura · 2025Review
- Social dominance in rats is a determinant of susceptibility to stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Distinguishing neural ensembles in the infralimbic cortex that regulate stress vulnerability and coping behavior.Neurobiology of stress · 2025Article
- Microglial type I interferon signaling mediates chronic stress-induced synapse loss and social behavior deficits.Molecular psychiatry · 2025Article
- Behavioral tests for the assessment of social hierarchy in mice.Frontiers in behavioral neuroscience · 2025Review
- Mesocorticolimbic circuit mechanisms of social dominance behavior.Experimental & molecular medicine · 2024Review
- Activation of androgen receptor-expressing neurons in the posterior medial amygdala is associated with stress resistance in dominant male hamsters.Hormones and behavior · 2024Article
- Prior experience with behavioral control over stress facilitates social dominance.Neurobiology of stress · 2024Article
- Sex differences in dominance relationships in Syrian hamsters.Physiology & behavior · 2023Article
- Activation of cell-free mtDNA-TLR9 signaling mediates chronic stress-induced social behavior deficits.Molecular psychiatry · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
introductionDominance hierarchies of social animal groups are very sensitive to stress. Stress experienced prior to social interactions between conspecifics may be a determinant of their future social dynamics. Additionally, long-term occupancy of a specific hierarchical rank can have psychophysiological effects which increase vulnerability to future stressors.
methodsWe aimed to delineate differential effects of stress acting before or after hierarchy formation. We studied whether exposure to the chronic social defeat stress (CSDS) paradigm before a two-week-long hierarchy formation affected the attainment of a dominant status using the social confrontation tube test (TT). These animals were singly housed for at least one week before CSDS to decrease confounding effects of prior hierarchy experience. Additionally, we investigated whether social rank predicted vulnerability to CSDS, measured by a social interaction test.
resultsIn TT, mice termed as dominant (high rank) win the majority of social confrontations, while the subordinates (low rank) lose more often. Within newly established hierarchies of stress-naïve mice, the subordinate, but not dominant, mice exhibited significantly greater avoidance of novel social targets. However, following exposure to CSDS, both lowest- and highest-ranked mice exhibited susceptibility to stress as measured by decreased interactions with a novel social target. In contrast, after CSDS, both stress-susceptible (socially avoidant) and stress-resilient (social) mice were able to attain dominant ranks in newly established hierarchies.
conclusionThese results suggest that the response to CSDS did not determine social rank in new cohorts, but low-status mice in newly established groups exhibited lower sociability to novel social targets. Interestingly, exposure of a hierarchical social group to chronic social stress led to stress susceptibility in both high- and low-status mice as measured by social interaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.