ArticleBrain and behavior2021
Altered third-party punishment in Huntington's disease: A study using neuroeconomic games.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- Different depression: motivational anhedonia governs antidepressant efficacy in Huntington's disease.Brain communications · 2022Article
- Another Perspective on Huntington's Disease: Disease Burden in Family Members and Pre-Manifest HD When Compared to Genotype-Negative Participants from ENROLL-HD.Brain sciences · 2021Article
- Problems with Social Cognition and Decision-Making in Huntington's Disease: Why Is it Important?Brain sciences · 2021Review
- Altered third-party punishment in Huntington's disease: A study using neuroeconomic games.Brain and behavior · 2021Article
- Impaired social learning in patients with major depressive disorder revealed by a reinforcement learning model.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuntington's disease (HD) is a heritable degenerative brain disease caused by a mutation in the huntingtin gene with excessive repeats of the base triplet cytosine-adenine-guanine (CAG), which codes for the aminoacid glutamine. HD is associated with a broad spectrum of neurocognitive dysfunction, including deficits in social cognition. The appreciation of fairness rules and reciprocity has not been studied in HD. Based on theoretical considerations suggesting that brain regions known to be affected from HD are involved in economic decision-making, the present study sought to examine HD patients' performance in two neuroeconomic games.
methodsTwenty-nine manifest HD mutation carriers (20 males, nine females) performed an Ultimatum Game (UG) and a Dictator Game (DG) where third-party punishment of observed unfairness was required. In addition, patients were tested for neurocognition and the ability to understand other people's mental states ("theory of mind"). For comparison, a clinical control group of 30 patients with chronic schizophrenia, and 30 unaffected healthy controls matched for age and verbal intelligence took part in the study.
resultsPatients with HD had some appreciation of fairness rules, as they tended to reject unfair offers in the UG similar to controls. However, unlike the other two groups, individuals with HD did not punish observed unfairness from a third-party perspective. This lack of "altruistic punishment" was associated with deficits in executive functioning including working memory, inhibitory control and cognitive flexibility, and to a lesser degree with poor "theory of mind."
conclusionsHD seems to be associated with impairments in understanding of more complex rules of social exchange. Aside from deficits in executive functioning, this behavior could, in part, be linked to an inability to experience third-party punishment as rewarding.
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