ArticleJournal of diabetes investigation2021
Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus.
Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- The Role of Nailfold Videocapillaroscopy (NVC) in Evaluating Ocular Diseases: Insights into Retinal, Choroidal, and Optic Nerve Pathologies.Journal of clinical medicine · 2026Review
- Nailfold capillaroscopy in diabetic retinopathy: microvascular insights, clinical value, and translational challenges - a narrative review.Frontiers in endocrinology · 2026Review
- Non-rheumatologic indications of nail fold capillaroscopy: findings in type 2 diabetic patients with or without diabetic retinopathy: a cross-sectional study.Clinical rheumatology · 2025Article
- Non-ocular biomarkers for early diagnosis of diabetic retinopathy by non-invasive methods.Frontiers in endocrinology · 2025Review
- Nailfold capillary patterns in ballgame and endurance athletes.Frontiers in physiology · 2025Article
- Effects of cardiac rehabilitation on in vivo nailfold microcirculation in patients with cardiovascular disease.Heart and vessels · 2025Article
- Association between findings in nailfold capillaroscopy and diabetic retinopathy: a systematic review and Meta-analysis.International journal of ophthalmology · 2025Article
- Article
- Advances in the Insulin-Heart Axis: Current Therapies and Future Directions.International journal of molecular sciences · 2024Review
- Relationship between nailfold capillaroscopy parameters and the severity of diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Primordial Drivers of Diabetes Heart Disease: Comprehensive Insights into Insulin Resistance.Diabetes & metabolism journal · 2024Review
- Review
- Morphological analysis of the impact of diabetes on gingival capillaries with non-invasive blood flow scope - A preliminary study.Journal of dental sciences · 2023Article
- Recent updates in factors associated with incidence and screening of diabetic eye disease.Journal of diabetes investigation · 2023Article
- Changes and significance of retinal blood oxygen saturation and oxidative stress indexes in patients with diabetic retinopathy.World journal of diabetes · 2022Article
- Nailfold capillary patterns correlate with age, gender, lifestyle habits, and fingertip temperature.PloS one · 2022Article
- Association of abdominal obesity with crossing capillaries in the finger nailfold in type 2 diabetes mellitus.Diabetology international · 2021Article
- Association of crossing capillaries in the finger nailfold with diabetic retinopathy in type 2 diabetes mellitus.Journal of diabetes investigation · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
AIMS/
introductionCrossing capillaries in the finger nailfold might potentially be a novel diabetic retinopathy (DR) biomarker that could be assessed non-invasively in the clinical setting. However, the association between crossing capillaries and DR is controversial. This study aimed to investigate the association between the percentage of crossing capillaries in the finger nailfold and DR in patients with type 2 diabetes mellitus. MATERIALS AND
methodsThis cross-sectional study enrolled 108 type 2 diabetes mellitus patients (aged 40-75 years) who visited the outpatient diabetic clinic at Osaka University Hospital, Osaka, Japan, between May and October 2019. Capillary morphology was assessed using nailfold capillaroscopy based on the simple capillaroscopic definitions of the European League Against Rheumatism Study Group. Details of DR and other laboratory data were obtained from medical records. The association between the tertile of the percentage of the crossing capillary and DR was analyzed using multivariable logistic regression.
resultsAfter adjusting for age, sex, diabetes duration, glycated hemoglobin, systolic blood pressure, body mass index, and use of renin-angiotensin system inhibitor and antihyperlipidemic medication, the percentage of crossing capillaries was significantly associated with DR (multivariable-adjusted odds ratios for increasing tertiles of the percentage of crossing capillary: 1 [reference], 2.05 [95% confidence interval 0.53-7.94], and 4.33 [95% confidence interval 1.16-16.21]; P-trend = 0.028).
conclusionsA higher percentage of crossing capillaries in the nailfold was associated with a higher risk of DR, independent of traditional risk and inhibiting factors, in patients with type 2 diabetes mellitus.
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