Evidence map›Paper›PMID 33070275›Full record

ArticleMolecular and cellular biochemistry2021

Engrafted primary type-2 astrocytes improve the recovery of the nigrostriatal pathway in a rat model of Parkinson's disease.

Yanyun Sun, Xiao-Jun Lu, Xinghui Fu, Ye Zhang, Yan Zhan, Jiabing Liu, Lingxia Zhao, Chun-Lin Xia

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yanyun Sun *Boxi Institute of Clinical Anatomy and Cytoneurobiology Unit, Medical College of Soochow University, Suzhou, 215123, China.
Xiao-Jun Lu *Department of Neurology, First Peoples Hospital of Taicang, Taicang, Suzhou, China.
Xinghui FuBoxi Institute of Clinical Anatomy and Cytoneurobiology Unit, Medical College of Soochow University, Suzhou, 215123, China.
Ye ZhangBoxi Institute of Clinical Anatomy and Cytoneurobiology Unit, Medical College of Soochow University, Suzhou, 215123, China.
Yan ZhanBoxi Institute of Clinical Anatomy and Cytoneurobiology Unit, Medical College of Soochow University, Suzhou, 215123, China.
Jiabing LiuBoxi Institute of Clinical Anatomy and Cytoneurobiology Unit, Medical College of Soochow University, Suzhou, 215123, China.
Lingxia ZhaoBoxi Institute of Clinical Anatomy and Cytoneurobiology Unit, Medical College of Soochow University, Suzhou, 215123, China.
Chun-Lin XiaBoxi Institute of Clinical Anatomy and Cytoneurobiology Unit, Medical College of Soochow University, Suzhou, 215123, China. xclcnb@suda.edu.cn.ORCID http://orcid.org/0000-0003-1124-8979
Soochow University · CNTaizhou First People's Hospital · CN

Funding

Jiangsu Province Health Research Project YG201307National Natural Science Foundation of China 81701316Suzhou Science and Technology Plan sys2018025Suzhou Science and Technology Plan SYS2019025
6 · The paper itself

Abstract

Parkinson's disease (PD) is a disorder characterized by a progressive loss of the dopaminergic neurons in the substantia nigra and a depletion of the neurotransmitter dopamine in the striatum. Our published results indicate that fasciculation and elongation protein zeta-1 (FEZ1) plays a role in the astrocyte-mediated protection of dopamine neurons and regulation of the neuronal microenvironment during the progression of PD. In this study, we examined the effects of engrafted type-2 astrocytes (T2As) with high expression of FEZ1 on the improvement of the symptoms and functional reconstruction of PD rats. T2As were stereotactically transplanted into the striatum of rats with PD induced by 6-hydroxydopamine (6-OHDA). An examination of apomorphine (APO)-induced rotations was performed to evaluate dopamine neuron damage and motor functions. Remarkably, the grafted cells survived in the lesion environment for six weeks or longer after implantation. In addition, the transplantation of T2As decrease the average velocity and the duration time of the APO-induced rotations, and increase the actuation time, as measured in the rotation behavioural tests. In the substantia nigra, the transplantation of T2As reduced the PD-induced GFAP, TH and FEZ1 downregulation. The grafted cells exclusively migrated to other regions near the injection site in the striatum and differentiated into GFAP

Indexed as

Adaptor Proteins, Signal TransducingAdrenergic AgentsAnimalsApomorphineAstrocytesDisease Models, AnimalDopaminergic NeuronsMaleMotor ActivityOxidopamineParkinson DiseaseRatsRats, Sprague-DawleySubstantia NigraAdaptor Proteins, Signal TransducingAdrenergic AgentsApomorphineFez1 protein, ratOxidopamineFEZ1Monoamine neurotransmitterNigrostriatal pathwayParkinson’s diseaseType-2 astrocytes

Identifiers

PMID33070275
OpenAlexW3092745241

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.