ReviewJournal of bone and mineral metabolism2021
RANKL and osteoimmunology in periodontitis.
Review in Journal of bone and mineral metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Expression of IL-33 in subjects with periodontitis: a systematic review and meta-analysis.European journal of medical research · 2024Pooled it
- Increased of IL-18 levels are associated with periodontitis: a systematic review and meta-analysis.BMC oral health · 2024Pooled it
- Oral manifestations of patients with systemic sclerosis: a meta-analysis for case-controlled studies.BMC oral health · 2021Pooled it
- Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach.Journal of periodontology · 2026Article
- Notch Signalling Pathway in the Pathogenesis of Periodontitis: Research Progress.International dental journal · 2026Review
- Bone and Infections: An Osteoimmunological Interplay.International journal of molecular sciences · 2026Review
- Anti-Gingivitis and Anti-Osteoclastogenesis Effects of Ethanol Extract fromJournal of microbiology and biotechnology · 2026Article
- Toll-like receptor engaged in activation and osteoimmuno-cytokines production by unswitched memory B cells during periodontitis.Odontology · 2026Article
- Immunomodulatory effects of oral microbiota in the pathogenesis of rheumatoid arthritis.Frontiers in immunology · 2026Review
- Pharmacovigilance-Based Identification and Mechanistic Exploration of Periodontitis-Related Drugs.Journal of clinical periodontology · 2026Article
- Article
- Biological mechanisms governing the periodontal regenerative microenvironment: cellular crosstalk, extracellular matrix remodelling, and immunomodulation.Frontiers in cell and developmental biology · 2026Review
- Association Between Ethylene Oxide Exposure and Complete Edentulism in United States Adults.Life (Basel, Switzerland) · 2025Article
- Evaluating the Efficacy of Resveratrol-Containing Mouthwash as an Adjunct Treatment for Periodontitis: A Randomized Clinical Trial.European journal of dentistry · 2025Article
- Article
- Effect and mechanism of Sanqi () in treating periodontitis.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Article
- Association Between Severe Periodontitis and Cognitive Decline in Older Adults.Life (Basel, Switzerland) · 2024Article
- Experimental Periodontitis Increases Anxious Behavior and Worsens Cognitive Aspects and Systemic Oxidative Stress in Wistar Rats.Clinical and experimental dental research · 2024Article
- The role of interleukin-20 on inflammatory stress and periodontal tissue destruction in patients with metabolic syndrome and periodontitis.BMC oral health · 2024Observational
- Men with HIV have increased alveolar bone loss.BMC oral health · 2024Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis, one of the most common infectious diseases in humans, is characterized by inflammation of the periodontal tissue and subsequent destruction of the alveolar bone, which ultimately leads to tooth loss. Recently, it was revealed that the osteoclastic bone damage that occurs during periodontitis is dependent on the receptor activator of NF-kB ligand (RANKL) produced by osteoblastic cells and periodontal ligament cells. Immune cells provide essential cues for the RANKL induction that takes place during periodontal inflammation. The knowledge accumulated and experimental tools established in the field of "osteoimmunology" have made crucial contributions to a better understanding of periodontitis pathogenesis and, reciprocally, the investigation of periodontitis has provided important insights into the field. This review discusses the molecular mechanisms underlying periodontal bone loss by focusing on the osteoimmune interactions and RANKL.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.