ArticlePediatric research2021
Preterm birth and genitourinary tract infections: assessing gene-environment interaction.
Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Urinary tract infections and risk of preterm birth: a systematic review and meta-analysis.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Pooled it
- Maternal and neonatal outcomes of pregnancy complicated by urolithiasis: a systematic review and meta-analysis.Journal of nephrology · 2021Pooled it
- Environmental and genetic risk factors for preterm birth: interplays with stressful events during pregnancy.Pediatric research · 2025Article
- Association of maternal prenatal phthalate exposure and genetic polymorphisms of metabolic enzyme genes with spontaneous preterm birth: a nested case-control study in China.BMC pregnancy and childbirth · 2025Article
- Genetic susceptibility for retinopathy of prematurity and its associated comorbidities.Pediatric research · 2024Article
- Maternal-Fetal Complications in Renal Colic during Pregnancy: A Scoping Review.Journal of clinical medicine · 2024Article
- Gene-environment interactions and preterm birth predictors: A Bayesian network approach.Genetics and molecular biology · 2024Article
- Genes, exposures, and interactions on preterm birth risk: an exploratory study in an Argentine population.Journal of community genetics · 2022Article
- Sacral Neuromodulation in Pregnant Women-A Case Report and Literature Review.International journal of environmental research and public health · 2022Review
- Uncovering Evidence: Associations between Environmental Contaminants and Disparities in Women's Health.International journal of environmental research and public health · 2022Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreterm birth (PTB) is the leading cause of perinatal morbimortality worldwide. Genetic and environmental factors could raise PTB risk. The aim of this study was to analyze the contribution of the statistical interaction between genes and vaginal-urinary tract infections (VI-UTI) to the risk of PTB by clinical subtype.
methodsTwenty-four SNPs were genotyped in 18 candidate genes from 352 fetal triads and 106 maternal triads. Statistical interactions were evaluated with conditional logistic regression models based on genotypic transmission/disequilibrium test.
resultsIn PTB-idiopathic subtype mothers exposed to UTI, fetal SNPs rs11686474 (FSHR), rs4458044 (CRHR1, allele G), rs883319 (KCNN3), and maternal SNP rs1882435 (COL4A3) showed a nominal significant increment in prematurity risk. In preterm premature rupture of membranes (PPROM), fetal SNP rs2277698 (TIMP2) showed a nominal significant risk increment. In mothers exposed to VI, fetal SNP rs5742612 (IGF1) in PTB-PPROM and maternal SNP rs4458044 (CRHR1, allele C) in spontaneous PTB showed nominal significant increment in prematurity risk.
conclusionsCertain maternal and fetal genes linked to infectious/inflammatory and hormonal regulation processes increase prematurity risk according to clinical subtype when mothers are exposed to UTI or VI. These findings may help in the understanding of PTB etiology and PTB prevention. IMPACT: Preterm birth is a major cause of perinatal morbimortality worldwide and its etiology remains unknown. This work provides evidence on the statistical interaction of six genes with gestational vaginal or urinary infections leading to the occurrence of preterm births. Statistical interactions vary according to infection type, genotype (maternal and fetal), and clinical subtype of prematurity. Certain maternal and fetal genetic variants of genes linked to infectious/inflammatory and hormonal regulation processes would increase the risk of prematurity according to clinical subtype and infection type. Our findings may help in the study of etiology of preterm birth and its prevention.
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