Evidence map›Paper›PMID 33070095›Full record

ArticleThe International journal on drug policy2020

US drug overdose mortality: 2009-2018 increases affect young people who use drugs.

Dhruv S Gaur, Brendan P Jacka, Traci C Green, Elizabeth A Samuels, Scott E Hadland, Maxwell S Krieger, Jesse L Yedinak, Brandon D L Marshall

Open access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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  5. Racial/ethnic inequality in homelessness and drug overdose deaths in US States.Social psychiatry and psychiatric epidemiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Dhruv S GaurDepartment of Epidemiology, Brown University. 121 South Main Street, Providence, RI 02912, USA.
Brendan P JackaDepartment of Epidemiology, Brown University. 121 South Main Street, Providence, RI 02912, USA.
Traci C GreenDepartment of Epidemiology, Brown University. 121 South Main Street, Providence, RI 02912, USA; Department of Emergency Medicine, The Warren Alpert Medical School, Brown University. 55 Claverick Street, Suite 100, Providence, RI 02903, USA; Department of Emergency Medicine, Boston University School of Medicine. 771 Albany St, Room 1208, Boston, MA 02118, USA; Rhode Island Hospital, COBRE on Opioids and Overdose. 8 Third Street, 2nd Floor, Providence, RI 02906, USA.
Elizabeth A SamuelsDepartment of Emergency Medicine, The Warren Alpert Medical School, Brown University. 55 Claverick Street, Suite 100, Providence, RI 02903, USA.
Scott E HadlandGrayken Center for Addiction and Department of Pediatrics, Boston Medical Center. One Boston Medical Center Place, Boston, MA 02118, USA; Department of Pediatrics, Division of General Pediatrics, Boston University School of Medicine. 88 East Newton Street, Vose Hall Room 322, Boston, MA, USA, 02118.
Maxwell S KriegerDepartment of Epidemiology, Brown University. 121 South Main Street, Providence, RI 02912, USA.
Jesse L YedinakDepartment of Epidemiology, Brown University. 121 South Main Street, Providence, RI 02912, USA.
Brandon D L MarshallDepartment of Epidemiology, Brown University. 121 South Main Street, Providence, RI 02912, USA. Electronic address: brandon_marshall@brown.edu.
Brown University · USBoston University · USRhode Island Hospital · US

Funding

Project 4: Neonatal Abstinence Syndrome (NAS): Fetus to First YearsP20GM125507 · NIGMS · RHODE ISLAND HOSPITAL · PI Brandon David Lewis Marshall · 2018 to 2026
$23.4M
The Rhode Island Young Adult Prescription and Illicit Drug Study (RAPIDS): Responding to Fentanyl and Associated HarmsR01DA047975 · NIDA · BROWN UNIVERSITY · PI MARSHALL, BRANDON DAVID LEWIS · 2019 to 2023
$3.8M
NIDA NIH HHS R01 DA047975NIGMS NIH HHS P20 GM125507
6 · The paper itself

Abstract

purposeDrug overdose mortality remains a public health concern in many countries globally. In the US, overdoses involving synthetic opioids are the primary contributor to overdose mortality. We aimed to assess trends in overdose death due to synthetic opioids among young people and describe key demographic and temporal changes.

methodsData from the US National Vital Statistics System Multiple Cause of Death files for 2009-2018 were analysed to determine age-specific overdose death rates by region (i.e. east versus west of the Mississippi River). Age-adjusted overdose mortality rates were used to compare demographic differences in all drug and synthetic opioid overdose among young people (aged 15-34 years) using a joinpoint regression with Poisson-approximated standard errors.

resultsDriven by synthetic opioid overdose, the age burden of mortality shifted towards young people in eastern states and remained approximately constant in western states over the study period. The highest increases in drug overdose mortality rates were observed in young Black and Hispanic people and those living in large metropolitan areas.

conclusionsRapid changes in the demographics of overdose demonstrate distinct but overlapping US overdose sub-epidemics, and highlight the need for targeted interventions to reduce overdose risk in young people.

Indexed as

Drug OverdosePharmaceutical PreparationsAdolescentAdultAnalgesics, OpioidBlack or African AmericanHumansMississippiUnited StatesYoung AdultAnalgesics, OpioidPharmaceutical PreparationsFentanylHarm reductionOpioidsOverdoseSubstance useYoung people

Identifiers

PMID33070095
PMCPMC7769862
OpenAlexW3093047132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.