ReviewMolecular therapy : the journal of the American Society of Gene Therapy2020
Fetal and Maternal Safety Considerations for In Utero Therapy Clinical Trials: iFeTiS Consensus Statement.
Open access · hybridAbstract readConsensus StatementReview
In one paragraph
Review in Molecular therapy : the journal of the American Society of Gene Therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
6.2field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Current Status of Cellular and Gene-Based Therapies for Congenital Metabolic Disorders: A Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Evaluation of Maternal Safety Following Prenatal Cell and Gene Therapy for Hemophilia A.Prenatal diagnosis · 2026Article
- In utero therapy for spinal muscular atrophy: closer to clinical translation.Brain : a journal of neurology · 2025Review
- The evolving landscape of NF gene therapy: Hurdles and opportunities.Molecular therapy. Nucleic acids · 2025Review
- Transformative approaches in hemophilia management: from traditional therapies to prenatal stem cell treatment.Frontiers in bioengineering and biotechnology · 2025Review
- The Application of Engineered Nanomaterials in Perinatal Therapeutics.Small (Weinheim an der Bergstrasse, Germany) · 2024Review
- HumaneLife · 2024Article
- Embryo and fetal gene editing: Technical challenges and progress toward clinical applications.Molecular therapy. Methods & clinical development · 2024Review
- Fetal gene therapy.Journal of inherited metabolic disease · 2024Review
- Intrauterine enzyme replacement therapies for lysosomal storage disorders: Current developments and promising future prospects.Prenatal diagnosis · 2023Review
- Transplanting FVIII/ET3-secreting cells in fetal sheep increases FVIII levels long-term without inducing immunity or toxicity.Nature communications · 2023Article
- Acceptability of prenatal diagnosis and prenatal treatment of haemophilia using cell and gene therapies within US haemophilia community.Haemophilia : the official journal of the World Federation of Hemophilia · 2023Article
- Gene modification therapies for hereditary diseases in the fetus.Prenatal diagnosis · 2023Review
- Improving Development of Drug Treatments for Pregnant Women and the Fetus.Therapeutic innovation & regulatory science · 2022Review
- Clinical Assessment of Fetal Well-Being and Fetal Safety Indicators.Journal of clinical pharmacology · 2022Review
- Regenerative medicine: prenatal approaches.The Lancet. Child & adolescent health · 2022Review
- Beyond Abortion Clinics: How Overturning Roe Will Obstruct Life-Saving Research and Fetal Therapy.The American journal of bioethics : AJOB · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 12 institutions in 9 countries.
Rachel SagarPrenatal Cell and Gene Therapy Group, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London WC1E 6HX, UK.
Graça Almeida-PoradaInstitute for Regenerative Medicine, Wake Forest School of Medicine, Winston- Salem, NC 27101, USA.
Karin BlakemoreDivision of Maternal-Fetal Medicine, John's Hopkins, Baltimore, MD 21218, USA.
Jerry K Y ChanKK Women's and Children's Hospital, Duke-NUS Medical School, Singapore 229899, Singapore.
Mahesh ChoolaniDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Cecilia GötherströmDepartment of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, ANA Futura, Karolinska Institutet, 141 52 Huddinge, Sweden.
Agnes JaulentEspeRare Foundation, Avenue de Secheron 15, Geneva 1202, Switzerland.
Tippi C MacKenzieDepartment of Surgery and the Center for Maternal-Fetal Precision Medicine, University of California, San Francisco, San Francisco, CA, USA.
Citra MattarDepartment of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Christopher D PoradaInstitute for Regenerative Medicine, Wake Forest School of Medicine, Winston- Salem, NC 27101, USA.
William H PeranteauChildren's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Holm SchneiderDepartment of Paediatrics and Center for Ectodermal Dysplasias, University Hospital Erlangen, Erlangen, Germany.
Steven W ShawDepartment of Obstetrics and Gynecology, Taipei Chang Gung Memorial Hospital, Taipei, Taiwan.
Simon N WaddingtonPrenatal Cell and Gene Therapy Group, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London WC1E 6HX, UK; Wits/SAMRC Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Magnus WestgrenDepartment of Clinical Science, Intervention and Technology, Division of Obstetrics and Gynecology, ANA Futura, Karolinska Institutet, 141 52 Huddinge, Sweden.
Anna L DavidPrenatal Cell and Gene Therapy Group, Elizabeth Garrett Anderson Institute for Women's Health, University College London, London WC1E 6HX, UK; NIHR University College London Hospitals Biomedical Research Centre, 149 Tottenham Court Road, London W1T 7DN, UK; Department of Development and Regeneration, Katholieke Universiteit, Leuven, Belgium. Electronic address: a.david@ucl.ac.uk.
Karolinska Institutet · SENational University of Singapore · SGWake Forest University · USChang Gung Memorial Hospital · TWChildren's Hospital of Philadelphia · USDuke-NUS Medical School · SGEspeRare Foundation · CHKU Leuven · BEUniversitätsklinikum Erlangen · DEUniversity College London · GBUniversity of California, San Francisco · USUniversity of the Witwatersrand · ZA
Funding
In utero gene editing to cure a metabolic liver diseaseR01DK123049 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI PERANTEAU, WILLIAM H. · 2020 to 2024
$3.7MPrenatal Cell and Gene Therapy for Hemophilia AR01HL135853 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALMEIDA-PORADA, GRACA DUARTE, PORADA, CHRISTOPHER D · 2017 to 2020
$2.8MIn utero CRISPR-mediated gene editing to cure congenital monogenic disordersDP2HL152427 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI PERANTEAU, WILLIAM H. · 2019 to 2019
$2.6MPostnatal Cell-Based Therapies for Hemophilia AR01HL130856 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ALMEIDA-PORADA, GRACA DUARTE, PORADA, CHRISTOPHER D · 2016 to 2019
$2.5McGMP Manufacture Of FVIII-Expressing Placental Cells For Hemophilia AU01HL148681 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Graca Duarte Almeida-Porada · 2019 to 2026
$1.6MPrenatal pulmonary cell gene editing to cure monogenic lung diseasesR01HL151352 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI PERANTEAU, WILLIAM H. · 2020 to 2022
$1.2MDepartment of HealthMedical Research Council MR/P026494/1Medical Research Council MR/R015325/1NHLBI NIH HHS DP2 HL152427NHLBI NIH HHS R01 HL130856NHLBI NIH HHS R01 HL135853NHLBI NIH HHS R01 HL151352NHLBI NIH HHS U01 HL148681NIDDK NIH HHS R01 DK123049
Abstract
PubMed holds no abstract for this paper.
Indexed as
Clinical Trials as TopicCell- and Tissue-Based TherapyFemaleFetal TherapiesGenetic TherapyHumansPregnancyPrenatal Careadverse eventclinical trialfetalfetal therapyIn utero stem cell transplantationmaternalsafety
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.