Evidence map›Paper›PMID 33069238›Full record

ArticleJournal of neuroinflammation2020

Investigation of reactive astrogliosis effect on post-stroke cognitive impairment.

Kuo-Lun Huang, Ing-Tsung Hsiao, Meng-Yang Ho, Jung-Lung Hsu, Yeu-Jhy Chang, Ting-Yu Chang, Chi-Hung Liu, Chien-Hung Chang, Yi-Ming Wu, Kuan-Yi Wu and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Kuo-Lun HuangDepartment of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.ORCID http://orcid.org/0000-0001-8215-721X
Ing-Tsung HsiaoDepartment of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.
Meng-Yang HoDepartment of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.
Jung-Lung HsuDepartment of Neurology, New Taipei Municipal TuCheng Hospital, Chang Gung Memorial Hospital, Chang Gung University, New Taipei City, Taiwan.
Yeu-Jhy ChangDepartment of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.
Ting-Yu ChangDepartment of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.
Chi-Hung LiuDepartment of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.
Chien-Hung ChangDepartment of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.
Yi-Ming WuDepartment of Radiology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Kuan-Yi WuDepartment of Psychiatry, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Shiaw-Pyng WeyDepartment of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.
Tzu-Chen YenDepartment of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan.
Nobuyuki OkamuraDivision of Neuro-imaging, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Tsong-Hai LeeDepartment of Neurology, Linkou Chang Gung Memorial Hospital, and College of Medicine, Chang Gung University, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan. thlee@adm.cgmh.org.tw.
Kun-Ju LinDepartment of Nuclear Medicine and Molecular Imaging Center, Linkou Chang Gung Memorial Hospital, No. 5, Fuxing St., Guishan, Taoyuan, Taiwan. kunjulin@gmail.com.
Chang Gung University · TWChang Gung Memorial Hospital · TWTohoku University · JP

Funding

Chang Gung Memorial Hospital BMRP611, CORPG3J0342Chang Gung Memorial Hospital BMRPD69, CPRPG3H0011Chang Gung Memorial Hospital CMRPD1H0392Ministry of Science and Technology, Taiwan 106-2314-B-182-017-MY3Ministry of Science and Technology, Taiwan 106-2314-B-182A-026-MY3Ministry of Science and Technology, Taiwan 107-2314-B-182A-051
6 · The paper itself

Abstract

backgroundThe aim of this study is to investigate the associations between post-stroke cognitive impairment (PSCI) severity and reactive astrogliosis (RA) extent on normalized

methodsWe prospectively enrolled 63 amyloid-negative patients with first-ever stroke. Neurocognitive evaluation, MRI,

resultsTwenty-five of 63 stroke patients had PSCI. Patients with PSCI had older age, lower education, and more severe cortical atrophy and total Z-SUM scores. Total Z-SUM scores were significantly associated with general cognitive and executive functions at multiple regression models. Path analyses showed that stroke can exert cognitive influence directly by stroke itself as well as indirectly through RA, including total and ipsilateral Z-SUM scores, in patients with either right or left hemisphere stroke.

conclusionThe patterns and intensity of

Indexed as

AgedCognitive DysfunctionCross-Sectional StudiesFemaleGliosisHumansMagnetic Resonance ImagingMaleMental Status and Dementia TestsMiddle AgedPositron-Emission TomographyProspective StudiesStrokePETPost-stroke cognitive impairmentReactive astrogliosisStroke

Identifiers

PMID33069238
PMCPMC7568828
OpenAlexW3093032851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.