ArticleBMC neurology2020
Traumatic brain injury-the effects of patient age on treatment intensity and mortality.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Risk factors associated with moderate and severe traumatic brain injury mortality in admitted older adults: a retrospective, single-center study at a level II trauma center.Journal of trauma and injury · 2026Article
- CT-positive traumatic brain injury in patients ≥ 80 years: mortality and 6-months functional outcome.Acta neurochirurgica · 2026Article
- The Impact of Hemoglobin Transfusion Thresholds in Moderate-to-Severe Blunt Traumatic Brain Injury on 6-Month Neurologic Outcomes: A Systematic Review and Meta-Analysis.Neurology international · 2026Article
- ASA class is independently associated with 30-day mortality after mild traumatic brain injury with intracranial injury: a national retrospective cohort study.Acta neurochirurgica · 2026Article
- Pre-Clinical Models of Traumatic Brain Injury-A Narrative Review Towards "Animal Neuro-ICUs".Biomedicines · 2026Review
- Functional recovery of patients with moderate and severe traumatic brain injury after extended and standard early rehabilitation.Frontiers in human neuroscience · 2026Article
- Interleukin-6 and its association with outcome in traumatic brain injury: a prospective cohort.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Predicting Factors Associated with In-hospital Mortality in Traumatic Brain Injury.Asian journal of neurosurgery · 2025Article
- Possible limited justification for systematic head computed tomography scans based solely on antithrombotic therapy in elderly patients (aged 75 or older) with mild traumatic brain injury.Research in diagnostic and interventional imaging · 2025Article
- Decision-making in interhospital transfer of traumatic brain injury patients: exploring the perspectives of surgeons at general hospitals and neurosurgeons at neurotrauma centres.BMC health services research · 2025Article
- ASA score is an independent predictor of 1-year outcome after moderate-to-severe traumatic brain injury.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Development and validation of a model to predict cognitive impairment in traumatic brain injury patients: a prospective observational study.EClinicalMedicine · 2025Article
- Consensus on the management of traumatic brain injury in older adults: Results from a Delphi study.Brain & spine · 2025Article
- The effect of extended early rehabilitation on the treatment outcome of patients with moderate and severe traumatic brain injury.Frontiers in human neuroscience · 2025Article
- Neurosurgical management of geriatric patients with traumatic brain injury in a medium-developed Chinese city: a recent-years overview.Frontiers in neurology · 2025Article
- Predicting outcomes in severe traumatic brain injury: A prospective analysis of clinical, radiological, and laboratory indicators.Surgical neurology international · 2025Article
- A national perspective of ambulance clinicians' perceptions, experiences and decision-making processes when assessing older adults with a head injury: a mixed-methods study.British paramedic journal · 2024Article
- The impact of early surgery on mortality and functional recovery in older adults with traumatic intracranial lesions: a propensity score-based analysis.Acta neurochirurgica · 2024Article
- Trajectories of Recovery Following Traumatic Brain Injury Among Older Medicare Beneficiaries.Journal of neurotrauma · 2024Article
- ASA-score is associated with 90-day mortality after complicated mild traumatic brain injury - a retrospective cohort study.Acta neurochirurgica · 2024Article
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9 authors.
Funding
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Abstract
backgroundAgeing is associated with worse treatment outcome after traumatic brain injury (TBI). This association may lead to a self-fulfilling prophecy that affects treatment efficacy. The aim of the current study was to evaluate the role of treatment bias in patient outcomes by studying the intensity of diagnostic procedures, treatment, and overall 30-day mortality in different age groups of patients with TBI.
methodsIncluded in this study was consecutively admitted patients with TBI, aged ≥ 15 years, with a cerebral CT showing intracranial signs of trauma, during the time-period between 2015-2018. Data were extracted from our prospective quality control registry for admitted TBI patients. As a measure of management intensity in different age groups, we made a composite score, where placement of intracranial pressure monitor, ventilator treatment, and evacuation of intracranial mass lesion each gave one point. Uni- and multivariate survival analyses were performed using logistic multinomial regression.
resultsA total of 1,571 patients with TBI fulfilled the inclusion criteria. The median age was 58 years (range 15-98), 70% were men, and 39% were ≥ 65 years. Head injury severity was mild in 706 patients (45%), moderate in 437 (28%), and severe in 428 (27%). Increasing age was associated with less management intensity, as measured using the composite score, irrespective of head injury severity. Multivariate analyses showed that the following parameters had a significant association with an increased risk of death within 30 days of trauma: increasing age, severe comorbidities, severe TBI, Rotterdam CT-score ≥ 3, and low management intensity.
conclusionThe present study indicates that the management intensity of hospitalised patients with TBI decreased with advanced age and that low management intensity was associated with an increased risk of 30-day mortality. This suggests that the high mortality among elderly TBI patients may have an element of treatment bias and could in the future be limited with a more aggressive management regime.
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