Evidence map›Paper›PMID 33069069›Full record

ArticleBioorganic & medicinal chemistry2020

An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli.

Claudio Zambaldo, Minseob Koh, Fariborz Nasertorabi, Gye Won Han, Abhishek Chatterjee, Raymond C Stevens, Peter G Schultz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. "Not-so-popular" orthogonal pairs in genetic code expansion.Protein science : a publication of the Protein Society · 2023
    Review
  7. Generating EfficientACS chemical biology · 2022
    Article
  8. A Facile Platform to EngineerACS central science · 2022
    Article
  9. Reprogramming the genetic code.Nature reviews. Genetics · 2021
    Review
  10. Rational Design of Aptamer-Tagged tRNAs.International journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Claudio ZambaldoDepartment of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, United States.
Minseob KohDepartment of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, United States.
Fariborz NasertorabiDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, United States.
Gye Won HanDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, United States.
Abhishek ChatterjeeDepartment of Chemistry, Boston College, 2609 Beacon Street, 246B Merkert Chemistry Center, Chestnut Hill, MA 02467, United States. Electronic address: abhishek.chatterjee@bc.edu.
Raymond C StevensDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA 90089, United States. Electronic address: stevens@usc.edu.
Peter G SchultzDepartment of Chemistry and Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, United States. Electronic address: schultz@scripps.edu.
Scripps Research Institute · USUniversity of Southern California · USBoston College · US

Funding

IN VIVO INCORPORATION OF UNNATURAL AMINO ACIDSR01GM062159 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI SCHULTZ, PETER G · 2001 to 2022
$8.2M
A genetically encoded toolset to decipher the biology of post-translational modifications in the mammalian proteomeR35GM136437 · NIGMS · BOSTON COLLEGE · PI Abhishek Chatterjee · 2020 to 2026
$4.0M
NIGMS NIH HHS R01 GM062159NIGMS NIH HHS R35 GM136437
6 · The paper itself

Abstract

We report the development of the orthogonal amber-suppressor pair Archaeoglobus fulgidus seryl-tRNA (Af-tRNA

Indexed as

Amino AcidsArchaeoglobus fulgidusEscherichia coliMethanosarcinaProtein EngineeringRNA, TransferSerine-tRNA LigaseAmino AcidsRNA, TransferSerine-tRNA LigaseE. coli orthogonalityGenetic code expansionNon-canonical amino acidsSeryl-tRNA synthetaseX-ray crystallography

Identifiers

PMID33069069
PMCPMC9462667
OpenAlexW3046183556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.