Evidence map›Paper›PMID 33068929›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2020

Effects of phycocyanin on pulmonary and gut microbiota in a radiation-induced pulmonary fibrosis model.

Wenjun Li, Lina Lu, Bin Liu, Song Qin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 67 citations in OpenAlex.

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  16. Food science & nutrition · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Wenjun LiYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, PR China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, PR China.
Lina LuSchool of Chemical Engineering, Northwest Minzu University, Lanzhou, PR China.
Bin LiuSchool of Stomatology, Lanzhou University, Lanzhou, Gansu, PR China. Electronic address: binliu0736@126.com.
Song QinYantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai, PR China. Electronic address: sqin@yic.an.cn.
Institute of Oceanology · CNLanzhou University · CNMinzu University of China · CNYantai Institute of Coastal Zone Research · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveRadiation pneumonia and fibrosis are major clinical complications of radiotherapy for thoracic tumor patients, and may significantly reduce survival and quality of life. At present, no safe and effective radiation protection measures have been approved for clinical use. Phycocyanin, a protein responsible for photosynthesis from Spirulina, has been shown to have a variety of biological activities and to be beneficial for a variety of diseases, including pulmonary fibrosis. However, the preventive and protective effects of phycocyanin on radiation-induced pulmonary fibrosis have not been studied.

designX-ray single dose irradiation was used on the chest of mice to prepare a mouse model of pulmonary fibrosis, from which the effect of phycocyanin on pulmonary histopathologic change, pulmonary fibrosis, the microbiota in lung and gut, LPS, TNF-α, and IL-6 at different time after irradiation were evaluated.

resultsPhycocyanin alleviated the radiation-induced lung injury and reduced the level of inflammatory factors. Thorax irradiation led to the disorder in microbiota of the lung and gut. The variation trend of the diversity of the two tissues was opposite, but that of the microbiota composition was similar. The phycocyanin intervention regulated the composition of the lung and gut microbiota, transformed them into normal state, and reduced the level of LPS, which significantly reduced the abundance of inflammation-related bacteria, and increased the abundance of probiotics that produce short-chain fatty acids.

conclusionPhycocyanin could regulate the radiation-induced disorder in lung and gut microbiota of mice, and reduce the radiation-induced lung inflammation and fibrosis.

Indexed as

AnimalsGastrointestinal MicrobiomeInflammationLipopolysaccharidesMaleMiceMice, Inbred C57BLPhycocyaninPulmonary FibrosisRadiation Injuries, ExperimentalRadiation PneumonitisSpirulinaLipopolysaccharidesPhycocyaninMicrobiotaPhycocyaninPulmonary fibrosisThorax irradiation

Identifiers

PMID33068929
PMCPMC7556228
OpenAlexW3093218209

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.