Evidence map›Paper›PMID 33068691›Full record

Trial reportExperimental gerontology2021

Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial.

Sara A Harper, John R Bassler, Sujitha Peramsetty, Youfeng Yang, Lisa M Roberts, Devin Drummer, Robert T Mankowski, Christiaan Leeuwenburgh, Karina Ricart, Rakesh P Patel and 4 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental gerontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Sara A HarperDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Kinesiology and Health Science Department, Utah State University, Logan, UT, USA; Sorenson Legacy Foundation Center for Clinical Excellence, Utah State University, Logan, UT, USA. Electronic address: sara.harper@usu.edu.
John R BasslerDepartment of Biostatistics, University of Alabama at Birmingham, AL, USA. Electronic address: jbassle1@uab.edu.
Sujitha PeramsettyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Integrative Center for Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: gperam@uab.edu.
Youfeng YangDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Integrative Center for Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: youfengyang@uabmc.edu.
Lisa M RobertsDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Integrative Center for Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: lmroberts@uabmc.edu.
Devin DrummerCenter for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: drummerd@uab.edu.
Robert T MankowskiDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: r.mankowski@uflu.edu.
Christiaan LeeuwenburghDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: cleeuwen@flu.edu.
Karina RicartDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: karinaricart@uabmc.edu.
Rakesh P PatelDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: rakeshpatel@uabmc.edu.
Marcas M BammanCenter for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: mbamman@uab.edu.
Stephen D AntonDepartment of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA. Electronic address: santon@ufl.edu.
Byron C JaegerDepartment of Biostatistics, University of Alabama at Birmingham, AL, USA. Electronic address: bcjaeger@uab.edu.
Thomas W BufordDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Integrative Center for Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA; UAB Nathan Shock Center on the Basic Biology of Aging, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: twbuford@uabmc.edu.
University of Alabama at Birmingham · USUniversity of Florida · USFoundation Center · US

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Peihua Qiu · 2007 to 2026
$22.8M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2013 to 2026
$19.5M
Sex hormones and arthritis in a long lived animal modelP30AG050886 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianhua Zhang · 2015 to 2026
$11.3M
Rehabilitation Research Resource to Enhance Clinical Trials (ReACT)P2CHD086851 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BAMMAN, MARCAS M · 2015 to 2019
$7.1M
Interdisciplinary Training in Pathobiology and Rehabilitation Medicine.T32HD071866 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAMES RIMMER, Anna E. Thalacker-Mercer · 2012 to 2026
$4.8M
The essentiality of serine and glycine for skeletal muscle regeneration in agingR01AG075059 · NIA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI THALACKER-MERCER, ANNA E. · 2022 to 2025
$1.5M
Resveratrol and exercise to treat functional limitations in late lifeR21AG049974 · NIA · UNIVERSITY OF FLORIDA · PI BUFORD, THOMAS W · 2016 to 2017
$413k
American Heart Association-American Stroke Association 20POST34990005NIA NIH HHS P30 AG028740NIA NIH HHS P30 AG050886NIA NIH HHS R01 AG075059NIA NIH HHS R21 AG049974NICHD NIH HHS P2C HD086851NICHD NIH HHS T32 HD071866NIDDK NIH HHS P30 DK056336NIDDK NIH HHS P30 DK079626
6 · The paper itself

Abstract

purposeTo evaluate the safety and feasibility of combining exercise (EX) and resveratrol to treat older adults with physical function limitations.

methodsThree-arm, two-site pilot randomized, controlled trial (RCT) for community-dwelling adults (N = 60), 71.8 ± 6.3 years of age with functional limitations. Participants were randomized to receive either 12 weeks of (1) EX + placebo [EX0], (2) EX + 500 mg/day resveratrol [EX500], or (3) EX + 1000 mg/day resveratrol [EX1000]. EX consisted of two sessions a week for 12 weeks of center-based walking and whole-body resistance training. Safety was assessed through adverse events and feasibility through exercise session and supplement (placebo, or resveratrol) protocol adherence. Outcome measures included a battery of indices of physical function as well as skeletal muscle mitchondrial function. Data were adjusted for age and gender using the Intent-To-Treat approach.

resultsAdverse event frequency and type were similar between groups (n = 8 EX0, n = 12 EX500, and n = 7 EX1000). Overall, 85% of participants met the supplement adherence via pill counts while 82% met the exercise session adherence. Adjusted within group mean differences (95% confidence interval) from week 0 to 12 for gait speed ranged from -0.04 (EX0: -0.1, 0.03) m/s to 0.04 (EX1000: -0.02, 0.11) and the six-minute walk test mean differences were 9.45 (EX0: -9.02, 27.7), 22.9 (EX500: 4.18, 41.6), and 33.1 (EX1000: 13.8, 52.4) meters. Unadjusted mean differences for citrate synthase were -0.80 (EX0: -15.45, 13.84), -1.38 (EX500: -12.16, 9.39), and 7.75 (EX1000: -4.68, 20.18) mU/mg. COX activity mean within group changes ranged from -0.05 (EX0) to 0.06 (EX500) k/s/mg. Additional outcomes are detailed in the text.

conclusionThe pilot RCT indicated that combined EX + resveratrol was safe and feasible for older adults with functional limitations and may improve skeletal muscle mitochondrial function and mobility-related indices of physical function. A larger trial appears warranted and is needed to formally test these hypotheses.

Indexed as

ExerciseWalkingAgedExercise TherapyHumansPilot ProjectsResveratrolResveratrolAgingClinical trialExerciseFunctional statusMitochondria

Identifiers

PMID33068691
PMCPMC7855904
OpenAlexW3093276449

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.