Evidence map›Paper›PMID 33068634›Full record

ArticleBrain research2021

CaMKII binding to GluN2B at S1303 has no role in acute or inflammatory pain.

Uche P Maduka, Stephanie R White, Mei-Ling A Joiner, Johannes W Hell, Donna L Hammond

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Uche P MadukaDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, United States.
Stephanie R WhiteDepartment of Anesthesia, University of Iowa, Iowa City, IA, United States.
Mei-Ling A JoinerDepartment of Anesthesia, University of Iowa, Iowa City, IA, United States.
Johannes W HellDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, United States; Department of Pharmacology, University of California, Davis, CA, United States.
Donna L HammondDepartment of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, United States; Department of Anesthesia, University of Iowa, Iowa City, IA, United States. Electronic address: Donna-Hammond@uiowa.edu.
University of Iowa · USUniversity of California, Davis · US

Funding

UNIVERSITY OF IOWA CTSA FOR PEDIATRIC RESEARCHUL1RR024979 · NCRR · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2007 to 2011
$31.8M
The NMDA Receptor Interaction with CaMKIIR01NS046450 · NINDS · UNIVERSITY OF IOWA · PI HELL, JOHANNES W · 2003 to 2006
$1.1M
Presynaptic NMDAR Regulation of Substance P Release in the RVM After InjuryF31NS073250 · NINDS · UNIVERSITY OF IOWA · PI MADUKA, UCHECHUKWU PATRICK · 2011 to 2013
$77k
NCRR NIH HHS UL1 RR024979NINDS NIH HHS F31 NS073250NINDS NIH HHS R01 NS046450
6 · The paper itself

Abstract

Activation of Ca

Indexed as

AnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2Calcium SignalingCalmodulinCapsaicinFemaleInflammationMaleMiceMice, Inbred C57BLNociceptionPainProtein BindingReceptors, N-Methyl-D-AspartateCalcium-Calmodulin-Dependent Protein Kinase Type 2CalmodulinCapsaicinNR2B NMDA receptorReceptors, N-Methyl-D-AspartateCaMKIICapsaicinGluN2BNMDA receptorNociception

Identifiers

PMID33068634
PMCPMC7719074
OpenAlexW3092982632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.