Evidence map›Paper›PMID 33068410›Full record

ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2021

Urinary excretion of epidermal growth factor and rapid loss of kidney function.

Jon Viljar Norvik, Laura R Harskamp, Viji Nair, Kerby Shedden, Marit D Solbu, Bjørn O Eriksen, Matthias Kretzler, Ron T Gansevoort, Wenjun Ju, Toralf Melsom

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In one paragraph

Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

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  19. Early Post-Transplant Urinary EGF as a Potential Predictor of Long-Term Allograft Loss in Kidney Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Jon Viljar NorvikMetabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
Laura R HarskampDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Viji NairDepartment of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, USA.
Kerby SheddenDepartment of Statistics, University of Michigan, Ann Arbor, MI, USA.
Marit D SolbuMetabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
Bjørn O EriksenMetabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
Matthias KretzlerDepartment of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, USA.
Ron T GansevoortDepartment of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Wenjun JuDepartment of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, USA.
Toralf MelsomMetabolic and Renal Research Group, UiT The Arctic University of Norway, Tromsø, Norway.
University of Michigan–Ann Arbor · USUiT The Arctic University of Norway · NOUniversity Hospital of North Norway · NOUniversity Medical Center Groningen · NL

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
University of Michigan O'Brien Kidney Translational Core CenterP30DK081943 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROSIUS, FRANK C · 2008 to 2022
$12.9M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK081943
6 · The paper itself

Abstract

backgroundLower urinary excretion of the kidney tubule-specific biomarker epidermal growth factor (uEGF) is associated with increased risk of renal function [glomerular filtration rate (GFR)] loss in diabetes and in patients with established chronic kidney disease (CKD). We investigated whether uEGF is associated with rapid GFR decline or incident CKD in the general population.

methodsSubjects without CKD or diabetes were recruited from the general population in Tromso, Norway [Renal Iohexol Clearance Survey (RENIS); N = 1249] and Groningen, the Netherlands [Prevention of REnal and Vascular END-stage disease (PREVEND); N = 4534], with a median follow-up of 5.6 and 7.4 years, respectively. GFR was measured by iohexol clearance in the RENIS and estimated using the CKD Epidemiology Collaboration creatinine-cystatin C equation in the PREVEND study. Rapid GFR decline was defined as an annual GFR loss >3.0 mL/min/1.73 m2 and in sensitivity analyses as subjects with the 10% steepest GFR slope within each cohort.

resultsLower baseline uEGF excretion was associated with rapid GFR loss in both cohorts {RENIS, odds ratio [OR] per 1 μg/mmol lower uEGF 1.42 [95% confidence interval (CI) 1.06-1.91], P = 0.02; PREVEND, OR 1.29 [95% CI 1.10-1.53], P < 0.01}, adjusted for baseline GFR, albumin:creatinine ratio and conventional CKD risk factors. Similar results were obtained using the outcome of the 10% steepest GFR slope in each cohort. Lower uEGF levels were associated with incident CKD in the combined analysis of both cohorts.

conclusionsLower uEGF levels are associated with increased risk of rapid GFR loss and incident CKD in the general population. This finding, together with previous findings in CKD and high-risk populations, supports that uEGF may serve as a broadly applicable biomarker representing the tubular component of the current glomerulus-centric clinical risk assessment system.

Indexed as

Epidermal Growth FactorRenal Insufficiency, ChronicCreatinineDisease ProgressionGlomerular Filtration RateHumansKidneyNetherlandsNorwayCreatinineEpidermal Growth Factorchronic kidney diseaseclinical epidemiologyepidermal growth factorrenal function declineuEGF

Identifiers

PMID33068410
PMCPMC8633454
OpenAlexW3093031665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.