Evidence map›Paper›PMID 33068333›Full record

ReviewDevelopmental neurobiology2021

The tubulin code specializes neuronal cilia for extracellular vesicle release.

Jyothi S Akella, Maureen M Barr

Open access · greenAbstract readReview
In one paragraph

Review in Developmental neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Journal of biosciences · 2025
    Review
  3. Extracellular vesicles.Genetics · 2024
    Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 2 countries.

Jyothi S AkellaDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0003-4839-4910
Maureen M BarrDepartment of Genetics and Human Genetics Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.ORCID 0000-0003-4483-2952
Rutgers, The State University of New Jersey · US

Funding

Polycystins, cilia, and extracellular vesicles in C. elegansR01DK059418 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Maureen M Barr · 2001 to 2026
$9.9M
Nephronophthisis-related ciliopathies and ciliary specializationR01DK116606 · NIDDK · RUTGERS, THE STATE UNIV OF N.J. · PI Maureen M Barr · 2018 to 2026
$3.7M
NIDDK NIH HHS R01 DK059418NIDDK NIH HHS R01 DK116606
6 · The paper itself

Abstract

Cilia are microtubule-based organelles that display diversity in morphology, ultrastructure, protein composition, and function. The ciliary microtubules of C. elegans sensory neurons exemplify this diversity and provide a paradigm to understand mechanisms driving ciliary specialization. Only a subset of ciliated neurons in C. elegans are specialized to make and release bioactive extracellular vesicles (EVs) into the environment. The cilia of extracellular vesicle releasing neurons have distinct axonemal features and specialized intraflagellar transport that are important for releasing EVs. In this review, we discuss the role of the tubulin code in the specialization of microtubules in cilia of EV releasing neurons.

Indexed as

Caenorhabditis elegans ProteinsExtracellular VesiclesAnimalsCaenorhabditis elegansCiliaSensory Receptor CellsTubulinCaenorhabditis elegans ProteinsTubulinC. elegansciliaciliopathyextracellular vesicleglutamylationintraflagellar transportkinesinmicrotubulepost-translational modificationstubulin code

Identifiers

PMID33068333
PMCPMC8052387
OpenAlexW3092698361

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.