ArticleBrain imaging and behavior2021
Association of brain white matter lesions with arterial stiffness assessed by cardio-ankle vascular index. The Beijing Vascular Disease Evaluation STudy (BEST).
Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Associations of Cerebrovascular Regulation and Arterial Stiffness With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2023Pooled it
- The association between total SVD score and cardio-ankle vascular index.Neuroradiology · 2026Article
- Lung Cancer Biomarkers Associated with Increased Peripheral Arterial Stiffness in Middle-aged Chinese Adults.Journal of atherosclerosis and thrombosis · 2025Article
- Endothelial Dysfunction under the Scope of Arterial Hypertension, Coronary Heart Disease, and Diabetes Mellitus using the Angioscan.Cardiovascular & hematological agents in medicinal chemistry · 2024Article
- Vascular Health Promotion Project and Vascular Medicine in China-CCVM2004-2023.Vascular health and risk management · 2023Review
- Clinical Evaluation Tool for Vascular Health-Endothelial Function and Cardiovascular Disease Management.Cells · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Background-The association of brain white matter lesions with arterial stiffness, as assessed by the cardio-ankle vascular index, is not well characterized in the population.
objectiveThe aim of this study was to quantify the cross-sectional association of brain white matter lesions with arterial stiffness assessed by the cardio-ankle vascular index among 1176 adults.
methodsWe used logistic regression to evaluate the associations of the cardio-ankle vascular index with brain white matter lesions, detected by computed tomography or magnetic resonance imaging, versus normal brain white matter.
resultsAfter adjustment for age, sex, systolic blood pressure, blood lipid level, C reactive protein level, homocysteine level, uric acid level, urea nitrogen level, creatinine level, hypertension, diabetes, coronary artery disease, peripheral artery disease, and stroke, the multivariable analysis showed that age, sex, systolic blood pressure, stroke and the cardio-ankle vascular index were independently associated with the presence of brain white matter lesions. Age range (odds ratio: from 2.48 to 33.64, all p < 0.05) showed the strongest association, followed by stroke (odds ratio: 7.16, 95% confidence interval: 4.59 to 11.16), male sex (odds ratio: 1.80, 95% confidence interval: 1.18 to 2.75), cardio-ankle vascular index (odds ratio: 1.26, 95% confidence interval: 1.06 to 1.50) and systolic blood pressure (odds ratio: 1.01, 95% confidence interval: 1.00 to 1.02).
conclusionHigher arterial stiffness assessed by the cardio-ankle vascular index was associated with the presence of brain white matter lesions. Longitudinal characterization of the observed associations is warranted to assess whether arterial stiffness predicts brain white matter lesions.
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