Evidence map›Paper›PMID 33068206›Full record

ArticleOdontology2021

Effects of ınjectable platelet-rich fibrin in experimental periodontitis in rats.

Hacer Sahin Aydinyurt, Tunahan Sancak, Cem Taskin, Yildiray Basbugan, Levent Akinci

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Odontology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06086249 (Clinical and Radiographic Success of Regeneration Using Injectable Platelet Rich Fibrin Versus Root Canal Treatment in Mature Permanent Molars With Apical Periodontitis), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06086249 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Clinical and Radiographic Success of Regeneration Using Injectable Platelet Rich Fibrin Versus Root Canal Treatment in Mature Permanent Molars With Apical Periodontitis: A Randomized Controlled Pilot Study

TypeinterventionalSponsorCairo UniversityRan2024 to 2025Enrolled50ConditionsApical PeriodontitisArmsRegeneration using Injectable platelet-rich fibrin, Root canal treatment
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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  9. Protective effect of carvacrol hydrogel on the alveolar bone in rats with periodontitis.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Hacer Sahin AydinyurtDepartment of Periodontology, Faculty of Dentistry, Van Yuzuncu Yil University, Campus, 65080, Van, Turkey. hacersahinay@gmail.com.tr.ORCID http://orcid.org/0000-0002-9521-9704
Tunahan SancakDepartment of Surgery, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Campus, 65080, Van, Turkey.
Cem TaskinDepartment of Periodontology, Faculty of Dentistry, Van Yuzuncu Yil University, Campus, 65080, Van, Turkey.
Yildiray BasbuganDepartment of Internal Diseases, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, Campus, 65080, Van, Turkey.
Levent AkinciDepartment of Endodontics, Faculty of Dentistry, Inonu University, Malatya, Turkey.
Van Yüzüncü Yıl Üniversitesi · TRInonu University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Injectable platelet-rich fibrin (i-PRF) is an effective biological material that positively contributes to angiogenesis, wound healing, inflammation, regeneration processes, etc. This research aimed to evaluate the effect of i-PRF in rats with experimental periodontitis. Following the development of ligature-induced periodontitis, 24 Wistar albino rats were divided into three groups. Group-1: scaling and root planing (only-SRP); Group-2: SRP + i-PRF; Group-3: only- i-PRF. Heart blood from six donors was used for the i-PRF application. i-PRF was administered as a subgingival injection in the relevant groups on the 1st, 3rd, and 7th days. The tissues were evaluated histopathologically and immunohistochemically. Also, bone structures were examined using micro-CT. According to the data obtained, no statistically significant difference was observed among the groups in terms of bone resorption, inflammation, bone volume, bone levels (mesial/distal), and IL-1β, IFN-ɤ, TNF-α, VEGF values (p > 0.05). However, bone mineral density was statistically significantly different among the groups (Group3 > Group2 > Group1) (p < 0.0001). Subgingival injection of only-i-PRF showed promising results in periodontitis treatment but contribution to SRP has not been proved according to this study results. The study results suggested that the i-PRF application was as effective as SRP in reducing bone loss, modulating inflammatory process, and effecting cytokines in experimental periodontitis. The significant effect of i-PRF on bone mineral density was the most remarkable result.

Indexed as

PeriodontitisPlatelet-Rich FibrinAnimalsRatsRats, WistarRoot PlaningWound HealingAnimal experimentationInterleukin-1betaPeriodontitisPlatelet-rich fibrinTumor necrosis factor-alphaVEGF

Identifiers

PMID33068206
OpenAlexW3092819231

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.