ArticlePediatric nephrology (Berlin, Germany)2021
Perinatal factors contributing to chronic kidney disease in a cohort of Japanese children with very low birth weight.
Article in Pediatric nephrology (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 17 citations in OpenAlex.
- Very preterm birth as a risk amplifier rather than a direct cause of chronic kidney disease and intellectual disability.Pediatric research · 2026Article
- Kidney care at NICU discharge and follow-up recommendations for preterm infants<34 weeks.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Continuous increase in podocyte numbers in the first 36 months of life-insights from forensic autopsies in Japanese children.Pediatric nephrology (Berlin, Germany) · 2025Article
- Chronic kidney disease associated with extremely premature birth and extremely low birth weight may progress through the burden of growth.CEN case reports · 2025Article
- Perinatal risk factors associated with acute kidney injury severity and duration among infants born extremely preterm.Pediatric research · 2024Article
- Risk factors for childhood chronic kidney disease: a population-based study.Pediatric nephrology (Berlin, Germany) · 2023Article
- Epidemiology of pediatric chronic kidney disease/kidney failure: learning from registries and cohort studies.Pediatric nephrology (Berlin, Germany) · 2022Review
- Developmental origins of disease highlight the immediate need for expanded access to comprehensive prenatal care.Frontiers in public health · 2022Article
- Association Analysis in Children Born from Normal and Complicated Pregnancies-Cardiovascular Disease Associated microRNAs and the Incidence of Prehypertension/Hypertension, Overweight/Obesity, Valve Problems and Heart Defects.International journal of molecular sciences · 2020Article
- Case-control study on long-term kidney outcomes in very low birth weight infants: impact of growth restriction and maternal preeclampsia.Jornal de pediatriaArticle
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Authors and funding
15 authors at 9 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDevelopmental programming of chronic kidney disease (CKD) in young adults is linked to preterm birth and intrauterine growth restriction (IUGR). Which confers a higher risk of progression to chronic kidney damage in children with very low birth weight (VLBW; born weighing < 1500 g): prematurity or IUGR?
methodsThis is a national historical cohort study of children with VLBW cared for in perinatal medical centers in Japan. Predictive factors included three latent variables (prematurity, IUGR, stress during neonatal period) and eight observed variables (gestational age, birth weight Z-score, maternal age, duration of treatment with antibiotics and diuretics, maternal smoking, late-onset circulatory collapse, kidney dysfunction) during the perinatal period. The primary endpoint was estimated glomerular filtration rate (eGFR) at age ≥ 3 years. A structural equation model was used to examine the pathologic constitution.
resultsThe 446 children with VLBW included 253 boys and 193 girls, of mean age 5.8 ± 2.6 years and mean eGFR 111.7 ml/min/1.73 m
conclusionsIUGR was more harmful to future kidneys of VLBW neonates. Neonatal kidney dysfunction and late-onset circulatory collapse were important risk factors for subsequent CKD development. This emphasizes the need for obstetricians to monitor for fetal growth restriction and neonatologists to minimize neonatal stress to prevent CKD in later life.
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