Evidence map›Paper›PMID 33068146›Full record

ArticleInternational orthopaedics2021

Allogeneic umbilical cord blood-derived mesenchymal stem cells combined with high tibial osteotomy: a retrospective study on safety and early results.

Young-Woo Chung, Hong-Yeol Yang, Sung-Ju Kang, Eun-Kyoo Song, Jong-Keun Seon

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Article in International orthopaedics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 6 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 6 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Young-Woo Chung *Department of Orthopedic Surgery, Gwangju Veterans Hospital, Gwangju, Republic of Korea.
Hong-Yeol Yang *Center for Joint Disease, Chonnam National University Bitgoeul Hospital, 80, Deoknamgil, Nam-gu, Gwangju, Republic of Korea.
Sung-Ju KangCenter for Joint Disease, Chonnam National University Bitgoeul Hospital, 80, Deoknamgil, Nam-gu, Gwangju, Republic of Korea.
Eun-Kyoo SongCenter for Joint Disease, Chonnam National University Bitgoeul Hospital, 80, Deoknamgil, Nam-gu, Gwangju, Republic of Korea.
Jong-Keun SeonCenter for Joint Disease, Chonnam National University Bitgoeul Hospital, 80, Deoknamgil, Nam-gu, Gwangju, Republic of Korea. seonbell@jnu.ac.kr.
Chonnam National University Hospital · KRVeterans Health Service Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCartilage repair performed as a single-stage procedure is an important advancement in the treatment of full-thickness cartilage injury and has potential for widespread clinical use. PURPOSE: To investigate the short-term outcomes and cartilage regeneration after implantation of allogeneic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in patients who received high tibial osteotomy (HTO) for symptomatic medial knee osteoarthritis.

methodsPatients underwent treatment of full-thickness chondral injury in the osteoarthritic knee with HTO and implantation of hUCB-MSCs and were followed prospectively for a minimum of one year. Ninety-three patients were followed for a mean 1.7 years (range, 1.0-3.5). Median cartilage lesion size was 6.5 cm

resultsAt final follow-up, the median IKDC subjective score had significantly improved from 39.0 to 71.3; the WOMAC score from 44.5 to 11.0; the KSS pain and function scores from 29.8 to 43.2 and 61.0 to 81.2, respectively; and the HSS from 61.6 to 82.7 (p < 0.05). Pre-operative examination showed ICRS grade IV cartilage injury in all knees, and cartilage regeneration at 2nd look arthroscopy showed improvements (8.2% of patients improved to ICRS grade I, 69.3% to grade II, and 22.5% to grade III). Moreover, Koshino stage was B in 24.5% and C in 75.5% of patients (p < 0.05).

conclusionAllogeneic hUCB-MSC implantation combined with HTO for medial knee osteoarthritis was safe and showed signs of cartilage status improvement. Furthermore, randomized controlled studies with a control group are necessary to determine the real effectiveness and indications of this new combined procedure for patients with osteoarthritis.

Indexed as

Cartilage, ArticularHematopoietic Stem Cell TransplantationMesenchymal Stem CellsMesenchymal Stem Cell TransplantationOsteoarthritis, KneeArthroscopyFetal BloodHumansKnee JointOsteotomyRetrospective StudiesTreatment OutcomeArticular cartilageKneeOsteotomyStem cell therapyUmbilical cord blood

Identifiers

PMID33068146
OpenAlexW3092800749

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.