ArticlePediatric radiology2021
Quantitative T1 mapping of the normal brain from early infancy to adulthood.
Article in Pediatric radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Abnormalities of thalamus and thalamocortical pathways in patients with refractory epilepsy caused by focal cortical dysplasia - MRI study.Epilepsia open · 2025Article
- Brain short TNeuroImage · 2025Article
- Microstructural imaging of brain changes in schizophrenia via quantitative T1 (qT1): a preliminary comparison of two acquisition protocols.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- TMagnetic resonance in medicine · 2025Article
- Synthetic MR: Clinical applications in neuroradiology.Neuroradiology · 2025Review
- Cortical microstructural changes in schizophrenia spectrum disorders using quantitative T1 mapping.Frontiers in psychiatry · 2025Article
- Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol.Developmental cognitive neuroscience · 2024Article
- A multi-institutional pediatric dataset of clinical radiology MRIs by the Children's Brain Tumor Network.ArXiv · 2023Article
- Brain deposition of gadobutrol in children-a cross-sectional and longitudinal MRI T1 mapping study.European radiology · 2023Article
- First clinical application of a novel T1 mapping of the whole brain.The neuroradiology journal · 2022Article
- High Periventricular T1 Relaxation Times Predict Gait Improvement After Spinal Tap in Patients with Idiopathic Normal Pressure Hydrocephalus.Clinical neuroradiology · 2022Article
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5 authors.
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Abstract
backgroundQuantitative mapping of MRI relaxation times is expected to uncover pathological processes in the brain more subtly than standard MRI techniques with weighted contrasts. So far, however, most mapping techniques suffer from a long measuring time, low spatial resolution or even sensitivity to magnetic field inhomogeneity.
objectiveTo obtain T1 relaxation times of the normal brain from early infancy to adulthood using a novel technique for fast and accurate T1 mapping at high spatial resolution. MATERIALS AND
methodsWe performed whole-brain T1 mapping within less than 3 min in 100 patients between 2 months and 18 years of age with normal brain at a field strength of 3 T. We analyzed T1 relaxation times in several gray-matter nuclei and white matter. Subsequently, we derived regression equations for mean value and confidence interval.
resultsT1 relaxation times of the pediatric brain rapidly decrease in all regions within the first 3 years of age, followed by a significantly weaker decrease until adulthood. These characteristics are more pronounced in white matter than in deep gray matter.
conclusionRegardless of age, quantitative T1 mapping of the pediatric brain is feasible in clinical practice. Normal age-dependent values should contribute to improved discrimination of subtle intracerebral alterations.
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