ArticleHLA2021
Development of an immunogenicity score for HLA-DQ eplets: A conceptual study.
Article in HLA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Eplet mismatch analysis in kidney transplantation: from concept to clinical practice.Clinical transplantation and research · 2025Review
- Variations in de novo donor-specific antibody development among HLA-DQ mismatches in kidney transplant recipients.PloS one · 2025Article
- Understanding HLA-DQ in renal transplantation: a mini-review.Frontiers in immunology · 2025Review
- Article
- A Short History of B-Cell HLA Epitopes.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Review
- Belatacept with time-limited tacrolimus coimmunosuppression modifies the 3-year risk of eplet mismatch in kidney transplantation.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Homozygosity in any HLA locus is a risk factor for specific antibody production: the taboo concept 2.0.Frontiers in immunology · 2024Article
- epiArt: a graphical HLA eplet amino acid repertoire translation reveals the need for an epitope driven revision of allele group nomenclature.Frontiers in genetics · 2024Article
- High-Risk HLA-DQ Mismatches Are Associated With Adverse Outcomes After Lung Transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024Article
- DQA1 Eplet Mismatch Load As an Independent Risk Factor of CLAD After Lung Transplantation.Transplantation direct · 2023Article
- Snowflake epitope matching correlates with child-specific antibodies during pregnancy and donor-specific antibodies after kidney transplantation.Frontiers in immunology · 2022Article
- Pediatric Kidney Transplantation-Can We Do Better? The Promise and Limitations of Epitope/Eplet Matching.Frontiers in pediatrics · 2022Review
- Progress in kidney transplantation: The role for systems immunology.Frontiers in medicine · 2022Review
- On Path to Informing Hierarchy of Eplet Mismatches as Determinants of Kidney Transplant Loss.Kidney international reports · 2021Article
- Outcome of Husband-to-Wife Kidney Transplantation With Mutual Children: Single Center Experience Using T Cell-Depleting Induction and Review of the Literature.Frontiers in medicine · 2021Article
- A Comprehensive Evaluation of the Antibody-Verified Status of Eplets Listed in the HLA Epitope Registry.Frontiers in immunology · 2021Article
- Article
- HLA-DQ-Specific Recombinant Human Monoclonal Antibodies Allow for In-Depth Analysis of HLA-DQ Epitopes.Frontiers in immunology · 2021Article
- Peptides Derived From Mismatched Paternal Human Leukocyte Antigen Predicted to Be Presented by HLA-DRB1, -DRB3/4/5, -DQ, and -DP Induce Child-Specific Antibodies in Pregnant Women.Frontiers in immunology · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eplets are defined as distinct amino acid configurations on the surface of HLA molecules. The aim of this study was to estimate the immunogenicity of HLA-DQ eplets in a cohort of 221 pregnancies with HLA-DQ mismatches. We defined the immunogenicity of an eplet by the frequency of antibody responses against it. Around 90% of all listed DQB1 or DQA1 eplets were at least five times mismatched and thus included for the calculation of their immunogenicity. The DQB1 eplets with the five highest immunogenicity scores were 55PP, 52PR, 52PQ, 85VG and 45EV; 25% of all DQB1 eplets were not reacting. The DQA1 eplets with the five highest immunogenicity scores were 25YS, 47QL, 55RR, 187T and 18S; 17% of all DQA1 eplets were not reacting. The immunogenicity score had a slightly higher area under the curve to predict development of child-specific antibodies than various molecular mismatch scores (eg, eplet mismatch load, amino acid mismatch load). Overlapping eplets were identified as a barrier to unambiguously assign the immunogenicity score based on HLA antibody reaction patterns. In this conceptual study, we explored the immunogenicity of HLA-DQ eplets and created a map of potentially immunogenic regions on HLA-DQ molecules, which requires validation in clinical transplant cohorts.
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