ArticleHuman brain mapping2021
Targeting the sensory feedback within the swallowing network-Reversing artificially induced pharyngolaryngeal hypesthesia by central and peripheral stimulation strategies.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- Efficacy and Mechanisms of Combined Central-Peripheral Magnetic Stimulation on Prefrontal-Sensorimotor Cortex Connectivity in Post-Stroke Dysphagia after Supratentorial Stroke: A Randomized, Single-Blind, Parallel-Controlled Trial.Translational stroke research · 2026Trial
- Effect of modified air-pulse stimulation on tracheotomised patients with dysphagia after stroke: A randomized clinical trial.Medicine · 2026Trial
- Pharyngeal electrical stimulation for postextubation dysphagia after stroke: a randomized trial on hospitalization costs from a health insurance perspective.Scientific reports · 2026Trial
- Metaplasticity in swallowing system via cross-modal neurostimulation: A randomized crossover trial with magnetoencephalography.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Trial
- Pharyngeal electrical stimulation to treat dysphagia in acute stroke: learnings from cases in the PhEED clinical trial.Journal of rehabilitation medicine · 2025Trial
- Treating postextubation dysphagia after stroke with pharyngeal electrical stimulation -insights from a randomized controlled pilot trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Trial
- Frequency-specific cortical subnetworks support fast human swallowing.Communications biology · 2026Article
- Post-stroke dysphagia is associated with abnormal gamma power and phase synchronisation during swallowing.Frontiers in human neuroscience · 2026Article
- Cognitive decline limits compensatory resource allocation within the aged swallowing network.GeroScience · 2025Article
- Morphological analysis and functional connectivity of the insular in patients with dysphagia after cerebral infarction based on resting-state fMRI.BMC neurology · 2025Article
- Clinical predictors of outcome after pharyngeal electrical stimulation (PES) in non-stroke related neurogenic dysphagia after mechanical ventilation and tracheotomy: results from subgroup analysis of PHADER study.Neurological research and practice · 2025Article
- Decannulation ahead: a comprehensive diagnostic and therapeutic framework for tracheotomized neurological patients.Neurological research and practice · 2025Review
- Predictors of pharyngeal electrical stimulation treatment success in tracheotomised stroke patients with dysphagia: Secondary analysis from PHADER cohort study.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024Article
- Relationship between post-stroke dysphagia and pharyngeal sensory impairment.Neurological research and practice · 2023Article
- Clinical features and power spectral entropy of electroencephalography in Wilson's disease with dystonia.Brain and behavior · 2022Article
- Can Swallowing Cerebral Neurophysiology Be Evaluated during Ecological Food Intake Conditions? A Systematic Literature Review.Journal of clinical medicine · 2022Review
- Clinical determinants and neural correlates of presbyphagia in community-dwelling older adults.Frontiers in aging neuroscience · 2022Article
- Exploration on neurobiological mechanisms of the central-peripheral-central closed-loop rehabilitation.Frontiers in cellular neuroscience · 2022Review
- Motor and sensory cortical processing of neural oscillatory activities revealed by human swallowing using intracranial electrodes.iScience · 2021Article
- Targeting the sensory feedback within the swallowing network-Reversing artificially induced pharyngolaryngeal hypesthesia by central and peripheral stimulation strategies.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pharyngolaryngeal hypesthesia is a major reason for dysphagia in various neurological diseases. Emerging neuromodulation devices have shown potential to foster dysphagia rehabilitation, but the optimal treatment strategy is unknown. Because functional imaging studies are difficult to conduct in severely ill patients, we induced a virtual sensory lesion in healthy volunteers and evaluated the effects of central and peripheral neurostimulation techniques. In a sham-controlled intervention study with crossover design on 10 participants, we tested the potential of (peripheral) pharyngeal electrical stimulation (PES) and (central) transcranial direct current stimulation (tDCS) to revert the effects of lidocaine-induced pharyngolaryngeal hypesthesia on central sensorimotor processing. Changes were observed during pharyngeal air-pulse stimulation and voluntary swallowing applying magnetoencephalography before and after the interventions. PES induced a significant (p < .05) increase of activation during swallowing in the bihemispheric sensorimotor network in alpha and low gamma frequency ranges, peaking in the right premotor and left primary sensory area, respectively. With pneumatic stimulation, significant activation increase was found after PES in high gamma peaking in the left premotor area. Significant changes of brain activation after tDCS could neither be detected for pneumatic stimulation nor for swallowing. Due to the peripheral cause of dysphagia in this model, PES was able to revert the detrimental effects of reduced sensory input on central processing, whereas tDCS was not. Results may have implications for therapeutic decisions in the clinical context.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.