ArticleJournal of the American Geriatrics Society2021
Cerebral Blood Flow in Patients with Severe Aortic Valve Stenosis Undergoing Transcatheter Aortic Valve Implantation.
Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Trial
- Expected Surgical Risk and the Risk of Stroke and Brain Injury After Transcatheter Aortic Valve Replacement: A Patient-Level Pooled Analysis.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Early cognitive and quality of life changes after transfemoral transcatheter aortic valve replacement.Medicine and pharmacy reports · 2025Article
- The Impact of Cognitive Impairment on Cardiovascular Disease.Journal of the American College of Cardiology · 2025Review
- The Heart-Brain Axis: Key Concepts in Neurocardiology.Cardiology discovery · 2025Review
- Cerebral blood flow and cognitive functioning in patients undergoing transcatheter aortic valve implantation.EClinicalMedicine · 2025Article
- Impact of surgical aortic valve replacement and transcatheter aortic valve implantation on cardiovascular and cerebrovascular controls: A pilot study.Physiological reports · 2024Article
- Treating Aortic Valve Stenosis for Vitality Improvement: The TAVI Study.Diseases (Basel, Switzerland) · 2024Article
- Cerebral blood flow and neurocognition in patients undergoing transcatheter aortic valve replacement for severe aortic stenosis.European heart journal open · 2024Article
- Cardiac output, cerebral blood flow and cognition in patients with severe aortic valve stenosis undergoing transcatheter aortic valve implantation: design and rationale of the CAPITA study.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2023Article
- App-based assessment of memory functions in patients after transfemoral aortic valve replacement.Journal of geriatric cardiology : JGC · 2023Article
- Neurovascular coupling in severe aortic valve stenosis.Brain and behavior · 2023Article
- Changes in cerebral autoregulation and vasoreactivity after surgical aortic valve replacement: a prospective study.Experimental physiology · 2023Article
- Excessive brain atrophy in patients with severe aortic stenosis.Polish journal of radiology · 2023Article
- Article
- Intraoperative hypotension and delirium among older adults undergoing transcatheter aortic valve replacement.Journal of the American Geriatrics Society · 2021Observational
- Central Hypovolemia Detection During Environmental Stress-A Role for Artificial Intelligence?Frontiers in physiology · 2021Review
- Predisposing and Precipitating Risk Factors for Delirium in Elderly Patients Admitted to a Cardiology Ward: An Observational Cohort Study in 1,042 Patients.Frontiers in cardiovascular medicine · 2021Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscatheter aortic valve implantation (TAVI) is a minimally invasive, life-saving treatment for patients with severe aortic valve stenosis that improves quality of life. We examined cardiac output and cerebral blood flow in patients undergoing TAVI to test the hypothesis that improved cardiac output after TAVI is associated with an increase in cerebral blood flow.
designProspective cohort study.
settingEuropean high-volume tertiary multidisciplinary cardiac care.
participantsThirty-one patients (78.3 ± 4.6 years; 61% female) with severe symptomatic aortic valve stenosis. MEASUREMENTS: Noninvasive prospective assessment of cardiac output (L/min) by inert gas rebreathing and cerebral blood flow of the total gray matter (mL/100 g per min) using arterial spin labeling magnetic resonance imaging in resting state less than 24 hours before TAVI and at 3-month follow-up. Cerebral blood flow change was defined as the difference relative to baseline.
resultsOn average, cardiac output in patients with severe aortic valve stenosis increased from 4.0 ± 1.1 to 5.4 ± 2.4 L/min after TAVI (P = .003). The increase in cerebral blood flow after TAVI strongly varied between patients (7% ± 24%; P = .41) and related to the increase in cardiac output, with an 8.2% (standard error = 2.3%; P = .003) increase in cerebral blood flow per every additional liter of cardiac output following the TAVI procedure.
conclusionFollowing TAVI, there was an association of increase in cardiac output with increase in cerebral blood flow. These findings encourage future larger studies to determine the influence of TAVI on cerebral blood flow and cognitive function.
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