ArticleBirth defects research2020
A multi-country study of prevalence and early childhood mortality among children with omphalocele.
Article in Birth defects research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Global birth prevalence of major congenital anomalies: a systematic review and meta-analysis.BMC public health · 2025Pooled it
- Analysis of early neonatal case fatality rate among newborns with congenital hydrocephalus, a 2000-2014 multi-country registry-based study.Birth defects research · 2022Pooled it
- The course and surgical management of a complex, giant omphalocele in a term neonate.Proceedings (Baylor University. Medical Center) · 2026Article
- Proxy-reported health-related quality of life in children with omphalocele: a cross-sectional study in China.Translational pediatrics · 2026Article
- Early postnatal C-reactive protein elevation during initial hospitalization in neonates with giant omphalocele undergoing delayed repair.Frontiers in pediatrics · 2026Article
- Beyond the Diagnosis: A Journey of an 8-Year-Old Girl with Patau Syndrome: Case Report.Children (Basel, Switzerland) · 2025Article
- Giant omphalocele with right lung agenesia and bronchial tracheal hypoplasia: A case report.Radiology case reports · 2024Article
- Prevalence of Congenital Anomalies in Iran.Archives of Iranian medicine · 2024Article
- Anatomic parameters of omphaloceles and their association with anatomic, genetic, or syndromic malformations: a retrospective study.Pediatric surgery international · 2024Article
- Ruptured giant omphalocele with congenital short small intestine: a case report.Frontiers in nutrition · 2024Article
- Neonate with an abnormal umbilicus.Journal of the American College of Emergency Physicians open · 2023Article
- Omphalocele: clinical and epidemiological profile of patients born in a tertiary care center in Rio de Janeiro.BMC pregnancy and childbirth · 2023Article
- Omphalocele and Cardiac Abnormalities-The Importance of the Association.Diagnostics (Basel, Switzerland) · 2023Review
- Successful on-ECLS Repair of CDH and Omphalocele in a Newborn.European journal of pediatric surgery reports · 2023Article
- Current Challenges in the Treatment of the Omphalocele-Experience of a Tertiary Center from Romania.Journal of clinical medicine · 2022Article
- Short and Medium-term Outcomes of Omphalocele and Gastroschisis: A Survey from a Tertiary Center.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022Article
- Why are Birth Defects Surveillance Programs Important?Frontiers in public health · 2021Article
- The Global Burden of Major Gastrointestinal Anomalies: A Global, Systematic Review of Gastrointestinal Anomaly Birth Prevalence.Sage open pediatricsReview
Corrections and comments
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Authors and funding
30 authors at 20 institutions in 17 countries.
Funding
Abstract
backgroundOmphalocele is the second most common abdominal birth defect and often occurs with other structural and genetic defects. The objective of this study was to determine omphalocele prevalence, time trends, and mortality during early childhood, by geographical region, and the presence of associated anomalies.
methodsWe conducted a retrospective study with 23 birth defect surveillance systems in 18 countries who are members of the International Clearinghouse for Birth Defects Surveillance and Research that submitted data on cases ascertained from 2000 through 2012, approximately 16 million pregnancies were surveyed that resulted in live births, stillbirths, or elective terminations of pregnancy for fetal anomalies (ETOPFA) and cases with omphalocele were included. Overall prevalence and mortality rates for specific ages were calculated (day of birth, neonatal, infant, and early childhood). We used Kaplan-Meier estimates with 95% confidence intervals (CI) to calculate cumulative mortality and joinpoint regression for time trend analyses.
resultsThe prevalence of omphalocele was 2.6 per 10,000 births (95% CI: 2.5, 2.7) and showed no temporal change from 2000-2012 (average annual percent change = -0.19%, p = .52). The overall mortality rate was 32.1% (95% CI: 30.2, 34.0). Most deaths occurred during the neonatal period and among children with multiple anomalies or syndromic omphalocele. Prevalence and mortality varied by registry type (e.g., hospital- vs. population-based) and inclusion or exclusion of ETOPFA.
conclusionsThe prevalence of omphalocele showed no temporal change from 2000-2012. Approximately one-third of children with omphalocele did not survive early childhood with most deaths occurring in the neonatal period.
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