Observational studyTranslational stroke research2021
Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke.
Observational study in Translational stroke research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 46 citations in OpenAlex.
- Impact of recognition of genetic information related to BMI on changes in physical activity, dietary intake, and blood cholesterol level: a randomized controlled trial.European journal of nutrition · 2025Trial
- Plasma Metabolites Link Dietary Patterns to Stroke Risk.Annals of neurology · 2023Trial
- Reduced Serum Uric Acid and Albumin Levels in Patients with Migraine: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Brain metabolomic profiling reveals ischemia-dominant disruption of metabolic pathways and tissue homeostasis in neonatal hypoxic-ischemic brain injury.Scientific reports · 2026Article
- Article
- Metabolic Signatures of Air Pollution and Major Adverse Cardiovascular Events in Patients Undergoing Cardiac Catheterization.JACC. Advances · 2026Article
- Persistent urinary metabolic signatures in children with type 1 diabetes.Next research · 2025Article
- Electroacupuncture ameliorates cognitive dysfunction in T2DM rats by modulating astrocytic polarization and aberrant energy metabolism in the hippocampus via the Wnt/β-catenin pathway.Diabetology & metabolic syndrome · 2025Article
- The fecal metabolome and microbiome are altered in dogs with idiopathic epilepsy compared to healthy dogs.Scientific reports · 2025Article
- Plasma metabolome reveals altered oxidative stress, inflammation, and amino acid metabolism in dogs with idiopathic epilepsy.Epilepsia · 2025Article
- Progress and perspectives of metabolic biomarkers in blood sample for diabetic microvascular complications.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- Mild Blast Exposure Dysregulates Metabolic Pathways and Correlation Networking as Evident from LC-MS-Based Plasma Profiling.Molecular neurobiology · 2025Article
- High-Resolution LC-MS Simultaneous Quantification of Forty-Six Compounds fromMolecules (Basel, Switzerland) · 2025Article
- Serum metabolic profiling of patients with diabetic kidney disease based on gas chromatography-mass spectrometry.Frontiers in molecular biosciences · 2025Article
- Identifying metabolic parameters as key indicators of hyperuricemia and ischemic stroke comorbidity via interpretable Clinlabomics models.Frontiers in endocrinology · 2025Article
- Metabolite signatures of chronological age, aging, survival, and longevity.Cell reports · 2024Article
- Acetylglutamine Differentially Associated with First-Time Versus Recurrent Stroke.Translational stroke research · 2024Observational
- The Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet and Metabolites in Chronic Kidney Disease.Nutrients · 2024Article
- Sex-Associated Metabolites and Incident Stroke, Incident Coronary Heart Disease, Hypertension, and Chronic Kidney Disease in the REGARDS Cohort.Journal of the American Heart Association · 2024Article
- Plasma Metabolites and Life's Simple 7 in REGARDS.Stroke · 2024Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Hyperglycemia is a feature of worse brain injury after acute ischemic stroke, but the underlying metabolic changes and the link to cytotoxic brain injury are not fully understood. In this observational study, we applied regression and machine learning classification analyses to identify metabolites associated with hyperglycemia and a neuroimaging proxy for cytotoxic brain injury. Metabolomics and lipidomics were carried out using liquid chromatography-tandem mass spectrometry in admission plasma samples from 381 patients presenting with an acute stroke. Glucose was measured by a central clinical laboratory, and a subgroup of patients (n = 201) had apparent diffusion coefficient (ADC) imaging quantified on magnetic resonance imaging (MRI) to estimate cytotoxic injury. Uric acid was the leading metabolite in univariate analysis of both hyperglycemia (OR 19.6, 95% CI 8.6-44.7, P = 1.44 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.