Evidence map›Paper›PMID 33067775›Full record

ArticleJournal of cancer survivorship : research and practice2021

Body composition and its association with fatigue in the first 2 years after colorectal cancer diagnosis.

H van Baar, M J L Bours, S Beijer, M van Zutphen, F J B van Duijnhoven, D E Kok, E Wesselink, J H W de Wilt, E Kampman, R M Winkels

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Article in Journal of cancer survivorship : research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Observational
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Review
  7. Article
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  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

H van BaarDivision of Human Nutrition and Health, Wageningen University & Research Wageningen, PO Box 17, 6700 AA, Wageningen, The Netherlands.ORCID 0000-0003-2705-5442
M J L BoursDepartment of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
S BeijerDepartment of Research & Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, The Netherlands.
M van ZutphenDivision of Human Nutrition and Health, Wageningen University & Research Wageningen, PO Box 17, 6700 AA, Wageningen, The Netherlands.
F J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University & Research Wageningen, PO Box 17, 6700 AA, Wageningen, The Netherlands.
D E KokDivision of Human Nutrition and Health, Wageningen University & Research Wageningen, PO Box 17, 6700 AA, Wageningen, The Netherlands.
E WesselinkDivision of Human Nutrition and Health, Wageningen University & Research Wageningen, PO Box 17, 6700 AA, Wageningen, The Netherlands.
J H W de WiltDepartment of Surgery, Radboud Universitair Medisch Centrum, Nijmegen, The Netherlands.
E KampmanDivision of Human Nutrition and Health, Wageningen University & Research Wageningen, PO Box 17, 6700 AA, Wageningen, The Netherlands.
R M WinkelsDivision of Human Nutrition and Health, Wageningen University & Research Wageningen, PO Box 17, 6700 AA, Wageningen, The Netherlands. renate.winkels@wur.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePersistent fatigue among colorectal cancer (CRC) patients might be associated with unfavorable body composition, but data are sparse and inconsistent. We studied how skeletal muscle index (SMI), skeletal muscle radiodensity (SMR), visceral adipose tissue (VAT), and subcutaneous adipose tissue (SAT) at diagnosis are associated with fatigue up to 24 months post-diagnosis in stage I-III CRC patients.

methodsSMI, SMR, VAT, and SAT were assessed among 646 CRC patients using pre-treatment computed tomography images. Fatigue at diagnosis, at 6, and 24 months post-diagnosis was assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire. The association of SMI, SMR, VAT, and SAT with fatigue (yes/no) was assessed using confounder-adjusted restricted cubic spline analyses.

resultsPrevalence of fatigue at diagnosis was 18%, at 6 months 25%, and at 24 months 12%. At diagnosis, a significant (p = 0.01) non-linear association of higher levels of SAT with higher prevalence of fatigue was observed. Lower levels of SMR were linearly associated with higher prevalence of fatigue at 6 months post-diagnosis (overall association p = 0.02). None of the body composition parameters were significantly associated with fatigue at 24 months.

conclusionHaving more SAT was associated with more fatigue at diagnosis, while low levels of SMR were associated with more fatigue at 6 months post-diagnosis. IMPLICATIONS FOR CANCER SURVIVORS: Our results suggest that it may be interesting to investigate whether interventions that aim to increase SMR around the time of diagnosis may help to lower fatigue. However, more knowledge is needed to understand the mechanisms behind the association of SMR with fatigue.

Indexed as

Colorectal NeoplasmsQuality of LifeBody CompositionFatigueHumansIntra-Abdominal FatAdipose tissueColorectal cancerFatigueFat massMuscle massSkeletal muscle radiodensity

Identifiers

PMID33067775
PMCPMC8272706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.