Evidence map›Paper›PMID 33067714›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2020

Comprehensive lipidomic profiling in serum and multiple tissues from a mouse model of diabetes.

Zhen Chen, Qiangrong Liang, Yue Wu, Zijun Gao, Satoru Kobayashi, Joy Patel, Cairong Li, Fei Cai, Youhua Zhang, Chongsheng Liang and 2 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. The Effects of Glyphosate and RoundupMolecules (Basel, Switzerland) · 2025
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  8. Lipid metabolism is dysregulated in a mouse model of diabetes.Metabolomics : Official journal of the Metabolomic Society · 2022
    Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Zhen ChenFaculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo, 060-0812, Japan.
Qiangrong LiangDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, 11548, USA.
Yue WuFaculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo, 060-0812, Japan.
Zijun GaoFaculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo, 060-0812, Japan.
Satoru KobayashiDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, 11548, USA.
Joy PatelDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, 11548, USA.
Cairong LiClinical Medical College, Hubei University of Science and Technology, 437100, Xianning, China.
Fei CaiHubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, 437100, Xianning, China.
Youhua ZhangDepartment of Biomedical Sciences, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY, 11548, USA.
Chongsheng LiangFaculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo, 060-0812, Japan.
Hitoshi ChibaDepartment of Nutrition, Sapporo University of Health Sciences, Nakanuma Nishi-4-2-1-15, Higashi, Sapporo, 007-0894, Japan.
Shu-Ping HuiFaculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo, 060-0812, Japan. keino@hs.hokudai.ac.jp.ORCID 0000-0001-9973-6461
Hokkaido University · JPNew York Institute of Technology · USHubei University of Science and Technology · CNSapporo University · JP

Funding

Deciphering the Role of Mitophagy in the Heart during FastingR15HL137130 · NHLBI · NEW YORK INST OF TECHNOLOGY · PI LIANG, QIANGRONG · 2018 to 2018
$427k
NHLBI NIH HHS R15 HL137130
6 · The paper itself

Abstract

introductionDiabetes mellitus is a serious metabolic disorder causing multiple organ damage in human. However, the lipidomic profiles in different organs and their associations are rarely studied in either diabetic patients or animals.

objectivesTo evaluate and compare the characteristics of lipid species in serum and multiple tissues in a diabetic mouse model.

methodsSemi-quantitative profiling analyses of intact and oxidized lipids were performed in serum and multiple tissues from a diabetic mouse model fed a high fat diet and treated with streptozotocin by using LC/HRMS and MS/MS. The total content of each lipid class, and the tissue-specific lipid species in all tissue samples were determined and compared by multivariate analyses.

resultsThe diabetic mouse model displayed characteristic differences in serum and multiple organs: the brain and heart showed the largest reduction in cardiolipin, while the kidney had more alterations in triacylglycerol. Interestingly, the lipidomic differences also existed between different regions of the same organ: cardiolipin species with highly polyunsaturated fatty acyls decreased only in atrium but not in ventricle, while renal cortex showed longer fatty acyl chains for both increased and decreased triacylglycerol species than renal medulla. Importantly, diabetes caused an accumulation of lipid hydroperoxides, suggesting that oxidative stress was induced in all organs except for the brain during the development of diabetes.

conclusionsThese findings provided novel insight into the organ-specific relationship between diabetes and lipid metabolism, which might be useful for evaluating not only diabetic tissue injury but also the effectiveness of diabetic treatments.

Indexed as

Lipid MetabolismLipidomicsAnimalsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2Lipid PeroxidationLipidsMiceOrgan SpecificityOxidative StressStreptozocinTandem Mass SpectrometryLipidsStreptozocinLipid hydroperoxidesLipidomicsMouse modelMultiple tissuesOxidative stressType 2 diabetes mellitus

Identifiers

PMID33067714
OpenAlexW3092885767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.