Evidence map›Paper›PMID 33067576›Full record

ArticleOncogene2020

MCU-dependent negative sorting of miR-4488 to extracellular vesicles enhances angiogenesis and promotes breast cancer metastatic colonization.

Xianchong Zheng, Sitong Lu, Zhanxin He, Hehai Huang, Zhuocheng Yao, Yutian Miao, Chunqing Cai, Fei Zou

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Xianchong Zheng *Department of Occupational Health and Occupational Medicine, School of Public Health, Southern Medical University, 510515, Guangzhou, China.ORCID http://orcid.org/0000-0002-8005-6519
Sitong Lu *Department of Occupational Health and Occupational Medicine, School of Public Health, Southern Medical University, 510515, Guangzhou, China.
Zhanxin HeDepartment of Occupational Health and Occupational Medicine, School of Public Health, Southern Medical University, 510515, Guangzhou, China.
Hehai HuangDepartment of Occupational Health and Occupational Medicine, School of Public Health, Southern Medical University, 510515, Guangzhou, China.
Zhuocheng YaoDepartment of Occupational Health and Occupational Medicine, School of Public Health, Southern Medical University, 510515, Guangzhou, China.
Yutian MiaoDepartment of Occupational Health and Occupational Medicine, School of Public Health, Southern Medical University, 510515, Guangzhou, China.
Chunqing CaiDepartment of Occupational Health and Occupational Medicine, School of Public Health, Southern Medical University, 510515, Guangzhou, China. h_zcn@126.com.ORCID http://orcid.org/0000-0003-1914-5472
Fei ZouDepartment of Occupational Health and Occupational Medicine, School of Public Health, Southern Medical University, 510515, Guangzhou, China. zfei@smu.edu.cn.ORCID http://orcid.org/0000-0002-1144-7540
Southern Medical University · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Based on Stephen Paget's well-established theory, both cell-autonomous and non-cell-autonomous mechanisms are crucial for metastasis. Although the mitochondrial calcium uniporter (MCU) has been suggested to be involved in breast cancer (BC) progression via cell-autonomous mechanisms, whether it assists the metastasis of BC cells through non-cell-autonomous mechanisms remains unclear. This study aimed to demonstrate that the MCU regulates BC metastatic colonization via non-cell-autonomous mechanisms. The results suggested that extracellular vesicles (EVs) derived from MCU-downregulated MDA-MB-231 cells suppressed angiogenesis in the metastatic niche in a nude mouse model, thereby hindering the colonization of BC cells. Mechanistically, we revealed that the MCU negatively correlated with miR-4488 in EVs derived from BC cells. Significantly, miR-4488 was determined to suppress angiogenesis of vascular endothelial cells by directly targeting angiogenic CX3CL1. Furthermore, we identified miR-4488 as being significantly downregulated in serum EVs from patients with triple-negative BC. Hence, this study suggests that MCU-dependent negative sorting of miR-4488 to EVs enhances angiogenesis in the metastatic niche and, thus, favors the metastatic colonization of BC cells.

Indexed as

AnimalsCalcium ChannelsCell Line, TumorCell MovementChemokine CX3CL1Circulating MicroRNADisease-Free SurvivalExtracellular VesiclesFemaleGene Expression Regulation, NeoplasticHumansHuman Umbilical Vein Endothelial CellsKaplan-Meier EstimateMiceMicroRNAsNeoplasm MetastasisCalcium ChannelsChemokine CX3CL1Circulating MicroRNACX3CL1 protein, humanMicroRNAsMIRN4488 microRNA, humanmitochondrial calcium uniporter

Identifiers

PMID33067576
OpenAlexW3092711700

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.