ArticleCommunications biology2020
Quantification of clinically applicable stimulation parameters for precision near-organ neuromodulation of human splenic nerves.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 27 citations in OpenAlex.
- Accelerating the development of bioelectronic medicine: outcomes and innovations from the NIH SPARC initiative.Bioelectronic medicine · 2026Review
- Splenic neuromodulation as monotherapy and in combination with biologic or targeted synthetic DMARDs for difficult-to-treat rheumatoid arthritis (ConsiderRAte): a randomised, sham-controlled, early feasibility trial.EClinicalMedicine · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Chronic neurostimulation of splenic nerve enabled by hydrogel-bioelectronics for wireless electroceutical immunomodulation therapy.National science review · 2026Article
- Simulation insights on the compound action potential in multifascicular nerves.PLoS computational biology · 2025Article
- Multi-Organ Denervation: The Past, Present and Future.Journal of clinical medicine · 2025Review
- A biodegradable capacitive-coupling neurostimulator for wireless electroceutical treatment of inflammatory bowel diseases.Science advances · 2025Article
- Highly-stable, injectable, conductive hydrogel for chronic neuromodulation.Nature communications · 2024Article
- Multi-Channel Microscale Nerve Cuffs for Spatially Selective Neuromodulation.Micromachines · 2024Article
- AxoDetect: an automated nerve image segmentation and quantification workflow for computational nerve modeling.Journal of neural engineering · 2024Article
- Functional Electrochemistry: On-Nerve Assessment of Electrode Materials for Electrochemistry and Functional Neurostimulation.IEEE open journal of engineering in medicine and biology · 2024Article
- Accelerating neurotechnology development using an Agile methodology.Frontiers in neuroscience · 2024Review
- Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies.Frontiers in integrative neuroscience · 2024Review
- Validated computational models predict vagus nerve stimulation thresholds in preclinical animals and humans.Journal of neural engineering · 2023Article
- Sympathetic innervation of human and porcine spleens: implications for between species variation in function.Bioelectronic medicine · 2022Article
- Peripheral nerve stimulation and immunity: the expanding opportunities for providing mechanistic insight and therapeutic intervention.International immunology · 2022Review
- Short-pulsed micro-magnetic stimulation of the vagus nerve.Frontiers in physiology · 2022Article
- Splenic arterial neurovascular bundle stimulation in esophagectomy: A feasibility and safety prospective cohort study.Frontiers in neuroscience · 2022Article
- Computational modelling of nerve stimulation and recording with peripheral visceral neural interfaces.Journal of neural engineering · 2021Article
- MorphoSONIC: A morphologically structured intramembrane cavitation model reveals fiber-specific neuromodulation by ultrasound.iScience · 2021Article
Corrections and comments
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Authors and funding
20 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuromodulation is a new therapeutic pathway to treat inflammatory conditions by modulating the electrical signalling pattern of the autonomic connections to the spleen. However, targeting this sub-division of the nervous system presents specific challenges in translating nerve stimulation parameters. Firstly, autonomic nerves are typically embedded non-uniformly among visceral and connective tissues with complex interfacing requirements. Secondly, these nerves contain axons with populations of varying phenotypes leading to complexities for axon engagement and activation. Thirdly, clinical translational of methodologies attained using preclinical animal models are limited due to heterogeneity of the intra- and inter-species comparative anatomy and physiology. Here we demonstrate how this can be accomplished by the use of in silico modelling of target anatomy, and validation of these estimations through ex vivo human tissue electrophysiology studies. Neuroelectrical models are developed to address the challenges in translation of parameters, which provides strong input criteria for device design and dose selection prior to a first-in-human trial.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.