ArticleScientific reports2020
Non-invasive vagus nerve stimulation attenuates proinflammatory cytokines and augments antioxidant levels in the brainstem and forebrain regions of Dahl salt sensitive rats.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- The brain-heart axis: effects of cardiovascular disease on the CNS and opportunities for central neuromodulation.Nature reviews. Neuroscience · 2026Review
- Non-Electrophilic Activation of NRF2 in Neurological Disorders: Therapeutic Promise of Non-Pharmacological Strategies.Antioxidants (Basel, Switzerland) · 2025Review
- Network pharmacology combined with experimental analysis to explore the mechanism of the XinShuaiNing formula on heart failure.3 Biotech · 2025Article
- Preoperative transcutaneous vagus nerve stimulation as a novel strategy to prevent postoperative atrial fibrillation in calcific aortic valve disease: mechanistic insights and translational perspectives.Frontiers in cardiovascular medicine · 2025Review
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) for Insomnia Disorder: A Narrative Review of Effectiveness, Mechanisms and Recommendations for Clinical Practice.Nature and science of sleep · 2025Review
- The vagus nerve in cardiovascular physiology and pathophysiology: From evolutionary insights to clinical medicine.Seminars in cell & developmental biology · 2024Review
- Vagus Nerve Stimulation and Inflammation in Cardiovascular Disease: A State-of-the-Art Review.Journal of the American Heart Association · 2023Review
- Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging.Frontiers in neuroscience · 2023Review
- Afterload reduction after non-invasive vagus nerve stimulation in acute heart failure.Frontiers in human neuroscience · 2023Article
- Review
- Selective Vagus Nerve Stimulation as a Therapeutic Approach for the Treatment of ARDS: A Rationale for Neuro-Immunomodulation in COVID-19 Disease.Frontiers in neuroscience · 2021Review
- Vagus Nerve Stimulation Transiently Mitigates Chemotherapy-Induced Peripheral Neuropathy in Rats.Journal of pain research · 2020Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
The anti-inflammatory effects of vagus nerve stimulation are well known. It has recently been shown that low-level, transcutaneous stimulation of vagus nerve at the tragus (LLTS) reduces cardiac inflammation in a rat model of heart failure with preserved ejection fraction (HFpEF). The mechanisms by which LLTS affect the central neural circuits within the brain regions that are important for the regulation of cardiac vagal tone are not clear. Female Dahl salt-sensitive rats were initially fed with either low salt (LS) or high salt (HS) diet for a period of 6 weeks, followed by sham or active stimulation (LLTS) for 30 min daily for 4 weeks. To study the central effects of LLTS, four brainstem (SP5, NAb, NTS, and RVLM) and two forebrain sites (PVN and SFO) were examined. HS diet significantly increased the gene expression of proinflammatory cytokines in the SP5 and SFO. LLTS reversed HS diet-induced changes at both these sites. Furthermore, LLTS augmented the levels of antioxidant Nrf2 in the SP5 and SFO. Taken together, these findings suggest that LLTS has central anti-inflammatory and antioxidant properties that could mediate the neuromodulation of cardiac vagal tone in the rat model of HFpEF.
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