Evidence map›Paper›PMID 33067453›Full record

ArticleNature communications2020

Defining the impact of dietary macronutrient balance on PCOS traits.

Valentina Rodriguez Paris, Samantha M Solon-Biet, Alistair M Senior, Melissa C Edwards, Reena Desai, Nicodemus Tedla, Madeleine J Cox, William L Ledger, Robert B Gilchrist, Stephen J Simpson and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 79 citations in OpenAlex.

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  8. Distinct macronutrient ratios optimize offspring survival, growth, and maternal glucose tolerance across mouse reproduction.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Valentina Rodriguez ParisDiscipline of Obstetrics and Gynaecology, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, 2052, Australia.ORCID 0000-0002-0880-6661
Samantha M Solon-BietCharles Perkins Centre, University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0003-0608-958X
Alistair M SeniorCharles Perkins Centre, University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0001-9805-7280
Melissa C EdwardsDiscipline of Obstetrics and Gynaecology, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, 2052, Australia.
Reena DesaiAndrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, NSW, 2139, Australia.
Nicodemus TedlaSchool of Medical Sciences, Department of Pathology, University of New South Wales Sydney, Sydney, NSW, 2052, Australia.
Madeleine J CoxDiscipline of Obstetrics and Gynaecology, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, 2052, Australia.ORCID 0000-0001-6774-992X
William L LedgerDiscipline of Obstetrics and Gynaecology, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, 2052, Australia.ORCID 0000-0001-6465-4343
Robert B GilchristDiscipline of Obstetrics and Gynaecology, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, 2052, Australia.
Stephen J SimpsonCharles Perkins Centre, University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0003-0256-7687
David J HandelsmanAndrology Laboratory, ANZAC Research Institute, University of Sydney, Sydney, NSW, 2139, Australia.ORCID 0000-0002-4200-7476
Kirsty A WaltersDiscipline of Obstetrics and Gynaecology, School of Women's and Children's Health, University of New South Wales Sydney, Sydney, NSW, 2052, Australia. k.walters@unsw.edu.au.ORCID 0000-0002-1504-9734
The University of Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lifestyle, mainly dietary, interventions are first-line treatment for women with polycystic ovary syndrome (PCOS), but the optimal diet remains undefined. We combined a hyperandrogenized PCOS mouse model with a systematic macronutrient approach, to elucidate the impact of dietary macronutrients on the development of PCOS. We identify that an optimum dietary macronutrient balance of a low protein, medium carbohydrate and fat diet can ameliorate key PCOS reproductive traits. However, PCOS mice display a hindered ability for their metabolic system to respond to diet variations, and varying macronutrient balance did not have a beneficial effect on the development of metabolic PCOS traits. We reveal that PCOS traits in a hyperandrogenic PCOS mouse model are ameliorated selectively by diet, with reproductive traits displaying greater sensitivity than metabolic traits to dietary macronutrient balance. Hence, providing evidence to support the development of evidence-based dietary interventions as a promising strategy for the treatment of PCOS, especially reproductive traits.

Indexed as

AnimalsDietDiet, Protein-RestrictedFemaleHumansLife StyleMiceMice, Inbred C57BLNutrientsPolycystic Ovary SyndromeNutrients

Identifiers

PMID33067453
PMCPMC7568581
OpenAlexW3093094606

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.