ReviewNature communications2020
A high-stringency blueprint of the human proteome.
Abstract readReview
In one paragraph
Review in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.
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122citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
122 citing papers in PubMed.
- MetaTIS: a tool to predict cognate and near-cognate translation initiation sites in human.NAR genomics and bioinformatics · 2026Article
- A multiplex tissue resource for high-resolution spatial protein profiling in the Human Protein Atlas.Protein science : a publication of the Protein Society · 2026Article
- Bridging the gap: A systematic approach to integrating serum and plasma proteomic datasets for biomarker studies.Journal of pharmaceutical and biomedical analysis · 2026Article
- Rapid Production of Recombinant Human SLFN14 Ribonuclease and Stoichiometric Analysis by Mass Photometry.Journal of visualized experiments : JoVE · 2026Article
- The ProteomeXchange consortium in 2026: making proteomics data FAIR.Nucleic acids research · 2026Article
- A High-Resolution Subcellular Map of Proteins in Cells with Motile Cilia.Journal of proteome research · 2026Article
- DeepQR: single-molecule QR codes for optical gene-expression analysis.Nanophotonics (Berlin, Germany) · 2025Article
- Evaluation of PE5 Entries on the Human Proteome Project Target List.Journal of proteome research · 2025Article
- The evolution of analytical techniques for multiplex analysis of protein biomarkers.Expert review of proteomics · 2025Review
- Recombinant Protein Spectral Library (rPSL) DIA-MS method improves identification and quantification of low-abundance cancer-associated and kynurenine pathway proteins.Communications chemistry · 2025Article
- StageTip: a little giant unveiling the potential of mass spectrometry-based proteomics.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2025Review
- RNAi screening of uncharacterized genes identifies promising druggable targets in Schistosoma japonicum.PLoS pathogens · 2025Article
- Genomics and multiomics in the age of precision medicine.Pediatric research · 2025Review
- Implementation of multi-omics in diagnosis of pediatric rare diseases.Pediatric research · 2025Review
- Review
- Enhanced Discovery of Alternative Proteins (AltProts) in Mouse Cardiac Development Using Data-Independent Acquisition (DIA) Proteomics.Analytical chemistry · 2025Article
- Proteomic Profiling Towards a Better Understanding of Genetic Based Muscular Diseases: The Current Picture and a Look to the Future.Biomolecules · 2025Review
- Emergent properties of the lysine methylome reveal regulatory roles via protein interactions and histone mimicry.Epigenomics · 2025Article
- Metal Organic Layers-Based Sample Preparation Method for Membrane Proteome Analysis.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Proteomics and machine learning: Leveraging domain knowledge for feature selection in a skeletal muscle tissue meta-analysis.Heliyon · 2024Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors.
Subash AdhikariFaculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
Edouard C NiceFaculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
Eric W DeutschInstitute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.
Lydie LaneFaculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU, Michel-Servet 1, 1211, Geneva, Switzerland.ORCID 0000-0002-9818-3030
Gilbert S OmennDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109-2218, USA.ORCID 0000-0002-8976-6074
Stephen R PenningtonUCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
Young-Ki PaikYonsei Proteome Research Center, 50 Yonsei-ro, Sudaemoon-ku, Seoul, 120-749, South Korea.
Christopher M OverallFaculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-5844-2731
Fernando J CorralesFunctional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC, Proteored-ISCIII, 28049, Madrid, Spain.
Ileana M CristeaDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Jennifer E Van EykCedars Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Los Angeles, CA, 90048, USA.ORCID 0000-0001-9050-148X
Mathias UhlénScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.ORCID 0000-0002-4858-8056
Cecilia LindskogRudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden.ORCID 0000-0001-5611-1015
Daniel W ChanDepartment of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
Amos BairochFaculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU, Michel-Servet 1, 1211, Geneva, Switzerland.
James C WaddingtonUCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
Joshua L JusticeDepartment of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
Joshua LaBaerBiodesign Institute, Arizona State University, Tempe, AZ, USA.
Henry RodriguezOffice of Cancer Clinical Proteomics Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Fuchu HeState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
Markus KostrzewaBruker Daltonik GmbH, Microbiology and Diagnostics, Fahrenheitstrasse, 428359, Bremen, Germany.
Peipei PingCardiac Proteomics and Signaling Laboratory, Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Rebekah L GundryCardiOmics Program, Center for Heart and Vascular Research, Division of Cardiovascular Medicine and Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.ORCID 0000-0002-9263-833X
Peter StewartDepartment of Chemical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
Sanjeeva SrivastavaIndian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
Sudhir SrivastavaCancer Biomarkers Research Branch, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Suite 5E136, Rockville, MD, 20852, USA.
Fabio C S NogueiraProteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveria Ramos, 149, 21941-909, Rio de Janeiro, RJ, Brazil.
Gilberto B DomontProteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveria Ramos, 149, 21941-909, Rio de Janeiro, RJ, Brazil.
Yves VandenbrouckUniversity of Grenoble Alpes, Inserm, CEA, IRIG-BGE, U1038, 38000, Grenoble, France.ORCID 0000-0002-1292-373X
Maggie P Y LamDepartments of Medicine-Cardiology and Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Sara WennerstenDivision of Cardiology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Juan Antonio VizcainoEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.ORCID 0000-0002-3905-4335
Marc WilkinsSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.ORCID 0000-0002-5700-5684
Jochen M SchwenkScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.ORCID 0000-0001-8141-8449
Emma LundbergScience for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.ORCID 0000-0001-7034-0850
Nuno BandeiraDepartment of Computer Science and Engineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0404, La Jolla, CA, 92093-0404, USA.ORCID 0000-0001-8385-3655
Gyorgy Marko-VargaDepartment of Biomedical Engineering, Lund University, Lund, Sweden.
Susan T WeintraubDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center San Antonio, UT Health, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA.
Charles PineauUniversity of Rennes, Inserm, EHESP, IREST, UMR_S 1085, F-35042, Rennes, France.
Ulrike KusebauchInstitute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.ORCID 0000-0001-6162-7577
Robert L MoritzInstitute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.ORCID 0000-0002-3216-9447
Seong Beom AhnFaculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
Magnus PalmbladLeiden University Medical Center, Leiden, 2333, The Netherlands.
Michael P SnyderDepartment of Genetics, Stanford School of Medicine, Stanford, CA, 94305, USA.ORCID 0000-0003-0784-7987
Ruedi AebersoldInstitute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.ORCID 0000-0002-9576-3267
Mark S BakerFaculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia. mark.baker@mq.edu.au.ORCID 0000-0001-5858-4035
Funding
Systems BiologyU19AG023122 · NIA · TRANSLATIONAL GENOMICS RESEARCH INST · PI NICHOLAS Joseph SCHORK · 2004 to 2026
$102.6MStrategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3MGenomic and Proteomic Architecture of AtherosclerosisR01HL111362 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HERRINGTON, DAVID MCLEOD · 2012 to 2021
$17.2MClinical and Analytical Validation of Cancer BiomarkersU24CA115102 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHAN, DANIEL WANYUI · 2005 to 2021
$7.4MShortening the development cycle time of Trans Proteomic Pipeline tools with high performance computingR01GM087221 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC, MORITZ, ROBERT L · 2010 to 2021
$6.0MThe Comprehensive Proteome Characterization Center at Johns Hopkins: High Precision Discovery and Confirmation of Genoproteomic TargetsU24CA210985 · NCI · JOHNS HOPKINS UNIVERSITY · PI CHAN, DANIEL WANYUI, ZHANG, HUI · 2016 to 2020
$5.3MUniversity of Michigan Proteogenomics Data Analysis CenterU24CA210967 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M, DHANASEKARAN, SARAVANA M · 2016 to 2020
$4.1MMechanisms mediating immune response upon sensing of nuclear viral DNAR01GM114141 · NIGMS · PRINCETON UNIVERSITY · PI CRISTEA, ILEANA M. · 2015 to 2023
$2.6MAdvancing data and metadata standards for proteomics mass spectraR24GM127667 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI DEUTSCH, ERIC · 2017 to 2019
$1.2MNCI NIH HHS U24 CA115102NCI NIH HHS U24 CA210967NCI NIH HHS U24 CA210985NHLBI NIH HHS R01 HL111362NIA NIH HHS U19 AG023122NIEHS NIH HHS P30 ES017885NIGMS NIH HHS R01 GM087221NIGMS NIH HHS R01 GM114141NIGMS NIH HHS R24 GM127667Wellcome TrustWellcome Trust 208391/Z/17/ZWellcome Trust WT101477MA
Abstract
The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
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DiseaseHuman Genome ProjectHumansProteomeProteomicsProteome
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.